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首页> 外文期刊>Journal of chromatography, A: Including electrophoresis and other separation methods >Overcoming matrix effects using the dilution approach in multiresidue methods for fruits and vegetables
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Overcoming matrix effects using the dilution approach in multiresidue methods for fruits and vegetables

机译：在水果和蔬菜的多残留方法中使用稀释方法克服基质效应

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During recent years matrix effects in liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) have quickly become a major concern in food analysis. The phenomenon of ion suppression can lead to errors in the quantification of the analytes of interest, as well as can affect detection capability, precision, and accuracy of the method. Sample dilution is an easy and effective method to reduce interfering compounds, and so, to diminish matrix effects. In this work, matrix effects of 53 pesticides in three different matrices (orange, tomato and leek) were evaluated. Several dilutions of the matrix were tested in order to study the evolution of signal suppression. Dilution of the extracts led to a reduction of the signal suppression in most of the cases. A dilution factor of 15 demonstrated to be enough to eliminate most of the matrix effects, opening the possibility to perform quantification with solvent based standards in the majority of the cases. In those cases where signal suppression could not be reduced, a possible solution would be to use stable isotope-labelled internal standards for quantification of the problematic pesticides.
机译：近年来，液相色谱与串联质谱联用（LC-MS / MS）中的基质效应已迅速成为食品分析中的主要问题。离子抑制现象可能导致目标分析物定量错误，并且可能影响该方法的检测能力，精度和准确性。样品稀释是一种减少干扰化合物的简便有效的方法，因此可以减少基质效应。在这项工作中，评估了三种不同基质（橙色，番茄和韭菜）中53种农药的基质效应。为了研究信号抑制的演变，测试了几种稀释的基质。在大多数情况下，提取物的稀释导致信号抑制的降低。 15的稀释倍数足以消除大多数基质效应，从而在大多数情况下提供了使用基于溶剂的标准品进行定量的可能性。在无法抑制信号抑制的情况下，可能的解决方案是使用稳定的同位素标记内标对有问题的农药进行定量。

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