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首页> 外文期刊>Journal of chromatography, A: Including electrophoresis and other separation methods >Study on the matrix effect in the determination of selected pharmaceutical residues in seawater by solid-phase extraction and ultra-high-performance liquid chromatography-electrospray ionization low-energy collision-induced dissociation tandem mass spectrometry
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Study on the matrix effect in the determination of selected pharmaceutical residues in seawater by solid-phase extraction and ultra-high-performance liquid chromatography-electrospray ionization low-energy collision-induced dissociation tandem mass spectrometry

机译：固相萃取-超高效液相色谱-电喷雾电离低能碰撞诱导解离串联质谱法测定海水中药物残留的基质效应研究

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摘要

Matrix effect is a major problem when trace level pharmaceuticals in seawater were analyzed using solid-phase extraction (SPE) combined with high-performance liquid chromatography-electrospray ionization tandem mass spectrometry (HPLC-ESI-MS-MS). Therefore, efforts should be devoted to diminish matrix effect as much as possible. The present study investigates the matrix effect during the analysis of selected pharmaceutical residues (naproxen, ibuprofen, diclofenac and gemfibrozil) in seawater samples with ultra-high-performance liquid chromatography (UHPLC)-ESI low-energy collision-induced dissociation (CID) MS-MS. Solutions to reduce matrix effect were studied through optimization of SPE procedure and the employment of isotope-labeled analogues. Results showed that 30 mL of deionized water can efficiently diminish matrix effect and satisfactory absolute mean recoveries ranging from 73.5% to 120.5% were obtained in the optimized SPE condition. Isotope-labeled analogues employed as surrogates were found to be efficient to further compensate for matrix effect, with the relative mean recoveries ranging from 85.5% to 110.5%. The optimized method has been successfully applied for the analysis of target pharmaceutical residues in different seawater samples.
机译：当使用固相萃取（SPE）结合高效液相色谱-电喷雾电离串联质谱（HPLC-ESI-MS-MS）分析海水中的痕量药物时，基质效应是一个主要问题。因此，应努力减少基质效应。本研究调查了使用超高效液相色谱（UHPLC）-ESI低能碰撞诱导解离（CID）MS分析海水样品中选定的药物残留（萘普生，布洛芬，双氯芬酸和吉非贝齐）时的基质效应-多发性硬化症。通过优化SPE程序和使用同位素标记的类似物来研究降低基质效应的解决方案。结果表明，在优化的SPE条件下，使用30 mL的去离子水可以有效地降低基质效应，并且获得的令人满意的绝对平均回收率在73.5％至120.5％之间。发现用作替代物的同位素标记的类似物可有效地进一步补偿基质效应，相对平均回收率在85.5％至110.5％之间。该优化方法已成功应用于不同海水样品中目标药物残留的分析。

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