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首页> 外文期刊>Journal of chromatography, A: Including electrophoresis and other separation methods >Application of hydrophilic interaction chromatography for the analysis of polar contaminants in food and environmental samples
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Application of hydrophilic interaction chromatography for the analysis of polar contaminants in food and environmental samples

机译：亲水相互作用色谱法在食品和环境样品中极性污染物分析中的应用

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摘要

For the analysis of highly hydrophilic and polar compounds, Hydrophilic Interaction Chromatography (HILIC) has been established as a valuable complementary approach to reversed-phase liquid chromatography (RPLC). Moreover, the use of mobile phases with a high percentage of organic solvent in HILIC separation is beneficial for mass spectrometric (MS) detection, because of enhanced ionization which results in an increased sensitivity. In this review, various applications of HILIC are described for a number of environmental and food contaminants together with detailed methodological descriptions and the advantages or drawbacks of HILIC compared to other LC methods are critically discussed. In the first part of the review, an overview is given of the work that has been carried out with HILIC for the analysis of pharmaceuticals and pesticides in environmental samples. HILIC has shown its applicability for polar pharmaceuticals, such as antibiotics, estrogens and their metabolites, drugs of abuse, cytostatics, metformin and contrast agents. In the pesticide group, HILIC chromatography was helpful for polar phenylurea and organophosphorus pesticides. The second part of the review focuses on the analysis of antibiotic residues in food and feed with HILIC, while in the pesticide group, HILIC experiments have been reported for dithiocarbamates and quaternary ammonium compounds. The last chapter gives an overview of the analysis by HILIC of miscellaneous analytes in aquatic and food/feed samples.
机译：对于高亲水性和极性化合物的分析，亲水相互作用色谱法（HILIC）已被确立为反相液相色谱法（RPLC）的宝贵补充方法。此外，在HILIC分离中使用具有高百分比有机溶剂的流动相，对于质谱（MS）检测是有利的，因为离子化增强，导致灵敏度提高。在这篇综述中，针对许多环境和食品污染物描述了HILIC的各种应用，并附有详细的方法学说明，并严格讨论了HILIC与其他LC方法相比的优缺点。在审查的第一部分中，概述了与HILIC一起用于分析环境样品中的药物和农药的工作。 HILIC已显示其可用于极性药物，例如抗生素，雌激素及其代谢产物，滥用药物，细胞抑制剂，二甲双胍和造影剂。在农药组中，HILIC色谱法有助于极性苯基脲和有机磷农药。综述的第二部分着重于分析使用HILIC的食品和饲料中的抗生素残留，而在农药类别中，已报道了针对二硫代氨基甲酸酯和季铵化合物的HILIC实验。上一章概述了通过HILIC对水生和食品/饲料样品中的其他分析物进行分析的过程。

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