Comparison of ultra-high performance methods in liquid and supercritical fluid chromatography coupled to electrospray ionization - mass spectrometry for impurity profiling of drug candidates

Lemasson Elise; Bertin Sophie; Hennig Philippe; Lesellier Eric; West Caroline

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Comparison of ultra-high performance methods in liquid and supercritical fluid chromatography coupled to electrospray ionization - mass spectrometry for impurity profiling of drug candidates

机译：液相色谱和超临界液相色谱与电喷雾电离质谱联用超高效方法对候选药物进行杂质分析的比较

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Impurity profiling of organic products synthesized as possible drug candidates represents a major analytical challenge. Complementary analytical methods are required to ensure that all impurities are detected. Both high-performance liquid chromatography (HPLC) and supercritical fluid chromatography (SFC) can be used for this purpose.

机译：作为可能的候选药物合成的有机产品的杂质分析代表了主要的分析挑战。需要使用补充分析方法以确保检测到所有杂质。高效液相色谱（HPLC）和超临界流体色谱（SFC）均可用于此目的。

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《Journal of chromatography, A: Including electrophoresis and other separation methods》 |2016年第null期|共12页
作者
Lemasson Elise; Bertin Sophie; Hennig Philippe; Lesellier Eric; West Caroline;
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正文语种 eng
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关键词
High-resolution separations; Impurity profiling; Orthogonal methods; Performance comparison; Pharmaceutical ingredients;

机译：高分辨率分离;杂质分析;正交方法;性能比较;药物成分;

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1. Comparison of ultra-high performance methods in liquid and supercritical fluid chromatography coupled to electrospray ionization - mass spectrometry for impurity profiling of drug candidates [J] . Lemasson Elise, Bertin Sophie, Hennig Philippe, Journal of chromatography, A: Including electrophoresis and other separation methods . 2016,第Null期

机译：液相色谱和超临界液相色谱与电喷雾电离质谱联用超高效方法对候选药物进行杂质分析的比较
2. Development of supercritical fluid chromatography coupled with mass spectrometry method for characterization of a nonionic surfactant and comparison with liquid chromatography coupled with mass spectrometry method [J] . Journal of mass spectrometry: JMS . 2020,第5期

机译：超临界流体色谱法与质谱法耦合，与质谱法表征的谱分析及液相色谱比较
3. Rapid oligonucleotide drug impurity determination by direct spectral comparison of ion-pair reversed-phase high-performance liquid chromatography electrospray ionization mass spectrometry data [J] . Roussis Stilianos G., Koch Charlie, Capaldi Daniel, Rapid Communications in Mass Spectrometry: RCM . 2018,第14期

机译：通过直接光谱比较离子对反相高效液相色谱电喷雾电离质谱数据的快速寡核苷酸药物杂质测定
4. Analysis of Peptides in Plasma by High Performance Liquid Chromatography coupled with Electrospray ionization Mass Spectrometry [C] . Haiyan Fang, Yin Liu, Shufang Wang International Conference on Mechanical Properties of Materials and Information Technology . 2011

机译：通过高效液相色谱法耦合电喷雾电离质谱法分析等离子体中的肽
5. Liquid chromatography coupled with electrospray-ionization mass spectrometry and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry method development and applications for the analysis of food and medicinal herbs. [D] . Lee, Kim Chung. 2009

机译：液相色谱结合电喷雾电离质谱和基质辅助激光解吸/电离飞行时间质谱方法的发展及在食品和草药分析中的应用。
6. Chemical Profiling of Re-Du-Ning Injection by Ultra-Performance Liquid Chromatography Coupled with Electrospray Ionization Tandem Quadrupole Time-of-Flight Mass Spectrometry through the Screening of Diagnostic Ions in MSE Mode [O] . Haibo Li, Yang Yu, Zhenzhong Wang, -1

机译：通过在MSE模式下筛选诊断离子通过超高效液相色谱结合电喷雾电离串联四极杆飞行时间质谱对Re-Du-Ning注射液进行化学分析
7. Identification of Glycoside Compounds from Tobacco by High Performance Liquid Chromatography/Electrospray Ionization Linear Ion-Trap Tandem Mass Spectrometry Coupled with Electrospray Ionization Orbitrap Mass Spectrometry [O] . Chunxiao Jia, Yonghua Zhu, Jinjie Zhang, 2016

机译：通过高效液相色谱/电喷雾电离线性离子捕获糖苷化合物的鉴定用高效液相色谱/电喷雾电离线性离子捕获串联质谱法与电喷雾电离壁板质谱法耦合

Comparison of ultra-high performance methods in liquid and supercritical fluid chromatography coupled to electrospray ionization - mass spectrometry for impurity profiling of drug candidates

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