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Pitfalls in the pattern of bone marrow infiltration in lymphoproliferative disorders

机译：淋巴增生性疾病中骨髓浸润模式的陷阱

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Summary Diagnostic pitfalls in the biopsies of bone marrow (BM) involved in lymphoproliferative disorders may not be recognized by the pathologist, unless he is aware of them. Apparently uninvolved BM may prove to be infiltrated by neoplastic cells after immunohistochemistry or molecular techniques are applied. Moreover, overlap in the immunophenotypical profile between different lymphoma subtypes and the established exclusiveness of BM patterns of involvement in certain lymphomas, may lead to diagnostic underestimation or overinterpretation. This article approaches the pitfalls in a systematic way, focusing primarily on the pattern of BM involvement in lymphoproliferative lesions as a potentially misleading diagnostic parameter. In this context, the presentation and discussion of pitfalls in terms of 'what should be considered' by the pathologist are preceded by a brief outline of 'what is known' for each disease entity that pitfalls refer to.
机译：总结病理学家可能无法识别参与淋巴增生性疾病的骨髓活检组织中的诊断缺陷，除非他意识到这些缺陷。免疫组织化学或分子技术应用后，未受累的BM可能被肿瘤细胞浸润。此外，不同淋巴瘤亚型之间的免疫表型谱重叠以及参与某些淋巴瘤的BM模式的已确定排他性可能导致诊断低估或过度解释。本文以系统的方式探讨了陷阱，主要集中在BM参与淋巴增生性病变中的模式作为潜在的误导性诊断参数。在这种情况下，病理学家根据“应该考虑什么”来介绍和讨论隐患，并简要概述了隐患所涉及的每个疾病实体的“已知信息”。

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