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An update on the pathophysiology of the intestinal crypt

机译:肠道隐窝的病理生理学更新

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摘要

The epithelial cells of the intestinal crypts enable the gut to perform its physiological functions. The intestinal stem cell is responsible for maintaining the epithelial cell population of the crypts. Little is known of the stem cells in terms of their identity, numbers and locations within the crypts. The accumulation of genetic mutations within stem cells and the subsequent spread of these mutated clones of cells leads to the growth of adenomas. This article will focus on the maintenance of the cell population of the intestinal crypts by the intestinal stem cell, and will consider the evidence relating to stem cell identity, location and function, the molecular regulation of stem cell function and the development and growth of epithelial tumours within the gastrointestinal tract.
机译:肠隐窝的上皮细胞使肠道能够执行其生理功能。肠干细胞负责维持隐窝的上皮细胞群。就干细胞的身份,数目和在隐窝内的位置而言,鲜为人知。干细胞内遗传突变的积累以及这些突变细胞克隆的后续传播导致腺瘤的生长。本文将重点关注肠道干细胞对肠道隐窝细胞群的维持,并考虑与干细胞身份,位置和功能,干细胞功能的分子调控以及上皮细胞的发育和生长有关的证据。胃肠道内的肿瘤。

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