Histamine h(3) receptor: a potential drug target for the treatment of central nervous system disorders.

Alguacil LF; Perez Garcia C

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Histamine h(3) receptor: a potential drug target for the treatment of central nervous system disorders.

机译：组胺h（3）受体：治疗中枢神经系统疾病的潜在药物靶标。

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Histamine H(3) receptors were first described in the eighties but finally cloned four years ago. They are G-protein coupled, mostly presynaptic, and are involved in the control of the synthesis and/or release of different neurotransmitters both in the central nervous system and the periphery. The availabiliy of specific ligands has permitted the study of potential therapeutic applications of either stimulating or blocking the function of these receptors. There is experimental evidence that drugs targeted at histamine H(3) receptors could be beneficial for neurodegenerative diseases such as Alzheimer and Parkinson's disease, epilepsy, drug abuse and several affective, appetite and sleeping disorders, among others. This review presents recent advances in this field.

机译：组胺H（3）受体在80年代首次被描述，但四年前才被克隆。它们是G蛋白偶联的，大多数是突触前的，并且参与中枢神经系统和外周中不同神经递质的合成和/或释放的控制。特定配体的可用性已允许研究刺激或阻断这些受体功能的潜在治疗应用。有实验证据表明，针对组胺H（3）受体的药物可能有益于神经退行性疾病，例如阿尔茨海默氏症和帕金森氏病，癫痫，药物滥用以及几种情感，食欲和睡眠障碍等。这篇评论介绍了该领域的最新进展。

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《Current drug targets. CNS and neurological disorders》 |2003年第5期|共11页
作者
Alguacil LF; Perez Garcia C;
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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
receptor; Histamine measurement; therapeutic aspects;

机译：受体;组胺测定;治疗方面;

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1. Histamine h(3) receptor: a potential drug target for the treatment of central nervous system disorders. [J] . Alguacil LF, Perez Garcia C Current drug targets. CNS and neurological disorders . 2003,第5期

机译：组胺h（3）受体：治疗中枢神经系统疾病的潜在药物靶标。
2. Functional Expression of Organic Ion Transporters in Astrocytes and Their Potential as a Drug Target in the Treatment of Central Nervous System Diseases [J] . Furihata Tomomi, Anzai Naohiko Biological & pharmaceutical bulletin . 2017,第8期

机译：中枢神经系统疾病治疗中枢神经系统患者的星形胶质细胞有机离子转运蛋白的功能表达
3. Implant-Assisted Intrathecal Magnetic Drug Targeting to Aid in Therapeutic Nanoparticle Localization for Potential Treatment of Central Nervous System Disorders [J] . Lueshen Eric, Venugopal Indu, Soni Tejen, Journal of biomedical nanotechnology . 2015,第2期

机译：植入物辅助鞘内磁性药物靶向治疗纳米颗粒定位的潜在治疗中枢神经系统疾病。
4. Photomechanical targeted drug and gene delivery to central nervous systems [C] . Sato Shunichi, Ando Takahiro, Satoh Yasushi, Conference on Lasers and Electro-Optics Pacific Rim . 2013

机译：光机械靶向药物和基因向中枢神经系统的传递
5. Modulation of the cannabinoid CB1 and CB2 receptor activation in central nervous system disorders. [D] . Zhang, Ming. 2008

机译：中枢神经系统疾病中大麻素CB1和CB2受体激活的调节。
6. Regional Differential Effects of the Novel Histamine H3 Receptor Antagonist 6-(3-Cyclobutyl-2345-tetrahydro-1H-3-benzazepin-7-yl)oxy-N-methyl-3-pyridinecarboxamide hydrochloride (GSK189254) on Histamine Release in the Central Nervous System of Freely Moving Rats [O] . Patrizia Giannoni, Andrew D. Medhurst, Maria Beatrice Passani, -1

机译：新型组胺H3受体拮抗剂6-（（3-Cyclobutyl-2345-tetrahydro-1H-3-benzazepin-7-yl）oxy -N-甲基-3-吡啶甲酰胺盐酸盐（ GSK189254）对自由运动大鼠中枢神经系统中组胺的释放
7. Histamine H3 receptor : a potential drug target for the treatment of central nervous system disorders/ L.F. Alguacil and C. Pérez-García. [O] . Alguacil Merino Luis Fernando ., Pérez-García Carmen coaut. 2003

机译：组胺H3受体：治疗中枢神经系统疾病的潜在药物靶点/ L.F.警长和C.pérez-García。
8. Drug Development and Conservation of Biodiversity in West and Central Africa: Performance of Neurochemical and Radio Receptor Assays of Plant Extracts Drug Discovery for the Central Nervous System [R] . Efange, S. , Mash, D. C. 2004

机译：西非和中非的药物开发和生物多样性保护：中枢神经系统的植物提取物的神经化学和无线电受体分析的发现

Histamine h(3) receptor: a potential drug target for the treatment of central nervous system disorders.

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