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首页> 外文期刊>Current drug targets. CNS and neurological disorders >Gastrointestinal disturbances in anorexia nervosa and bulimia nervosa.
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Gastrointestinal disturbances in anorexia nervosa and bulimia nervosa.

机译：神经性厌食症和神经性贪食症的胃肠道疾病。

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摘要

Disturbances in the functioning of the upper gastrointestinal (GI ) tract have been described in both Anorexia Nervosa (AN) and Bulimia Nervosa (BN). Patients with AN experience substantial delays in gastric emptying as well as constipation. These problems may give rise to significant medical complications and may contribute to increased difficulties with refeeding and weight restoration. Reported GI disturbances in BN include increased gastric capacity, diminished gastric relaxation, delayed gastric emptying, diminished release of cholecystokinin (CCK) and abnormalities of enteric autonomic function, all of which may play a role in perpetuation of the syndrome. This article reviews evidence for the most common disturbances of GI function in AN and BN and discusses potential GI targets for therapeutic intervention.
机译：在神经性厌食症（AN）和神经性贪食症（BN）中均已描述了上消化道（GI）的功能障碍。患有AN的患者出现胃排空和便秘的明显延迟。这些问题可能会引起严重的医学并发症，并可能导致增加进食和体重恢复的难度。据报道，BN的GI紊乱包括胃容量增加，胃松弛减少，胃排空延迟，胆囊收缩素（CCK）释放减少和肠道自主功能异常，所有这些都可能在该综合征的延续中起作用。本文回顾了AN和BN中最常见的GI功能障碍的证据，并讨论了用于治疗干预的潜在GI目标。

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