L-Cystine Diamides as L-Cystine Crystallization Inhibitors for Cystinuria

Hu Longqin; Yang Yanhui; Aloysius Herve; Albanyan Haifa; Yang Min; Liang Jian-Jie; Yu Anthony; Shtukenberg Alexander; Poloni Laura N.; Kholodovych Vladyslav; Tischfield Jay A.; Goldfarb David S.; Ward Michael D.; Sahota Amrik

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L-Cystine Diamides as L-Cystine Crystallization Inhibitors for Cystinuria

机译：L-胱氨酸二酰胺作为胱氨酸尿症的L-胱氨酸结晶抑制剂

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L-Cystine bismorpholide (la) and L-cystine bis(N'-methylpiperazide) (1b) were seven and twenty-four times more effective than L-cystine dimethyl ester (CDME) in increasing the metastable supersaturation range of L-cystine, respectively, effectively inhibiting L-cystine crystallization. This behavior can be attributed to inhibition of crystal growth at microscopic length scale, as revealed by atomic force microscopy. Both 1a and 1b are more stable than CDME, and 1b was effective in vivo in a knockout mouse model of cystinuria.

机译：L-胱氨酸双吗啉化物（Ia）和L-胱氨酸双（N'-甲基哌嗪）（1b）在增加L-胱氨酸的亚稳态过饱和范围方面比L-胱氨酸二甲基酯（CDME）高7到24倍，分别有效抑制L-胱氨酸的结晶。如原子力显微镜所揭示的，这种行为可以归因于在微观长度尺度上晶体生长的抑制。 1a和1b都比CDME更稳定，并且1b在半胱氨酸尿症的敲除小鼠模型中有效。

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《Journal of Medicinal Chemistry》 |2016年第15期|共6页
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Hu Longqin; Yang Yanhui; Aloysius Herve; Albanyan Haifa; Yang Min; Liang Jian-Jie; Yu Anthony; Shtukenberg Alexander; Poloni Laura N.; Kholodovych Vladyslav; Tischfield Jay A.; Goldfarb David S.; Ward Michael D.; Sahota Amrik;
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1. Design, synthesis, and evaluation of L-cystine diamides as L-cystine crystallization inhibitors for cystinuria [J] . Yang Yanhui, Albanyan Haifa, Lee Sumi, Bioorganic and Medicinal Chemistry Letters . 2018,第8期

机译：L-胱氨酸酰胺的设计，合成和评价为胱氨酸尿的L-胱氨酸结晶抑制剂
2. Dislocation-Actuated Growth and Inhibition of Hexagonal L-Cystine Crystallization at the Molecular Level [J] . Shtukenberg Alexander G., Poloni Laura N., Zhu Zina, Crystal growth & design . 2015,第2期

机译：分子水平上位错驱动的生长和六角形L-胱氨酸结晶的抑制。
3. Biomimetic crystallization of L-cystine hierarchical structures [J] . Ejgenberg M., Mastai Y. Crystal growth & design . 2012,第10期

机译：L-胱氨酸分层结构的仿生结晶
4. Synthesis and Optical Properties of L-cystine Capped ZnS:Co Nanoparticles [C] . P. Kumbhakar, R. Sarkar, A.K. Mitra NSTI-Nanotech 2010;NSTI nanotechnology conference and expo;Bio Nanotech 2010;NSTI bio nano conference and expo;Microtech 2010;Microtechnology conference and expo;WCM 2010;Workshop on compact modeling;NSTI nanotech ventures;TechConnect summit;Clean technology . 2010

机译：L-胱氨酸包覆的ZnS：Co纳米粒子的合成与光学性质
5. Investigation of L-cystine assisted Cu3BiS 3 synthesis for energetically and environmentally improved integration as thin-film solar cell p-type semiconductor absorber. [D] . Viezbicke, Brian D. 2015

机译：研究L-胱氨酸辅助的Cu3BiS 3合成在能量和环境方面的集成，以作为薄膜太阳能电池p型半导体吸收剂。
6. L-Cystine Diamides as L-Cystine Crystallization Inhibitors for Cystinuria [O] . Longqin Hu, Yanhui Yang, Herve Aloysius, -1

机译：L-胱氨酸二酰胺作为胱氨酸尿症的L-胱氨酸结晶抑制剂
7. Design, synthesis, and evaluation of l-cystine diamides as l-cystine crystallization inhibitors for cystinuria [O] . Yanhui Yang, Haifa Albanyan, Sumi Lee, 2018

机译：L-胱氨酸酰胺的设计，合成和评价为胱氨酸尿的L-胱氨酸结晶抑制剂

L-Cystine Diamides as L-Cystine Crystallization Inhibitors for Cystinuria

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