Transmembrane helix heterodimerization in lipid bilayers: Probing the energetics behind autosomal dominant growth disorders

Merzlyakov M; You M; Li E; Hristova K

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Transmembrane helix heterodimerization in lipid bilayers: Probing the energetics behind autosomal dominant growth disorders

机译：脂质双层中的跨膜螺旋异二聚化：探索常染色体显性生长障碍背后的能量学

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Here, we show that the energetics of transmembrane helix heterodimer formation can be characterized in liposomes using Forster resonance energy transfer (FRET). We present the theory and the protocol for measuring the free energy of heterodimerization, and the total (hetero and homo-dimeric) dimer fraction. We use the presented methodology to determine the propensity for heterodimer formation between wild-type fibroblast growth factor receptor 3 (FGFR3) transmembrane domain and the Ala391Glu mutant, linked to Crouzon syndrome with acanthosis nigricans. (c) 2006 Elsevier Ltd. All rights reserved.

机译：在这里，我们显示跨膜螺旋异二聚体形成的能量学可以使用Forster共振能量转移（FRET）在脂质体中表征。我们介绍了用于测量异二聚作用的自由能和总（杂二聚和同二聚）二聚体分数的理论和协议。我们使用提出的方法来确定野生型成纤维细胞生长因子受体3（FGFR3）跨膜结构域和Ala391Glu突变体，与黑棘皮病与克鲁佐综合症相关联的异二聚体形成的倾向。（c）2006 Elsevier Ltd.保留所有权利。

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《Journal of Molecular Biology》 |2006年第1期|共7页
作者
Merzlyakov M; You M; Li E; Hristova K;
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正文语种 eng
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heterodimer; FRET; receptor tyrosine kinase; fibroblast growth factor receptor 3; transmembrane domain; RESONANCE ENERGY-TRANSFER; RECEPTOR TYROSINE KINASE; ACANTHOSIS NIGRICANS; CROUZON-SYNDROME; MUTATIONS; DOMAIN; DIMERIZATION; ACHONDROPLASIA; STABILITY; MEMBRANES;

机译：异二聚体;FRET;受体酪氨酸激酶;成纤维细胞生长因子受体3;跨膜结构域;共振能量转移;受体酪氨酸激酶;尼古丁胶;古龙参多糖;突变;域;二聚化;软骨膜;稳定性;

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1. Transmembrane helix heterodimerization in lipid bilayers: Probing the energetics behind autosomal dominant growth disorders [J] . Merzlyakov M, You M, Li E, Journal of Molecular Biology . 2006,第1期

机译：脂质双层中的跨膜螺旋异二聚化：探索常染色体显性生长障碍背后的能量学
2. Cannabinoid CB1 receptor recognition of endocannabinoids via the lipid bilayer: molecular dynamics simulations of CB1 transmembrane helix 6 and anandamide in a phospholipid bilayer [J] . Lynch DL, Reggio PH Journal of Computer-Aided Molecular Design . 2006,第7a8期

机译：通过脂质双层识别大麻素的大麻素CB1受体：磷脂双层中CB1跨膜螺旋6和anandamide的分子动力学模拟
3. Cannabinoid CB1 receptor recognition of endocannabinoids via the lipid bilayer: molecular dynamics simulations of CB1 transmembrane helix 6 and anandamide in a phospholipid bilayer [J] . Diane L. Lynch, Patricia H. Reggio Journal of Computer-Aided Molecular Design . 2006,第7a8期

机译：通过脂质双层识别大麻素的大麻素CB1受体：磷脂双层中CB1跨膜螺旋6和anandamide的分子动力学模拟
4. Evaluation of lateral interactions between membrane gangliosidesand receptor transmembrane segments in lipid bilayers based onsemi-quantitative fluorescence analysis [C] . Mikito Nakano, Shinya Hanashima, Toshiaki Hara 日本化学会春季年会 . 2020

机译：基于血液定量荧光分析的脂质双层膜神经植物和受体跨膜段横向相互作用的评价
5. Transmembrane helix dimerization in lipid bilayers and mammalian membranes. [D] . Chen, Lirong. 2011

机译：脂质双层和哺乳动物膜中的跨膜螺旋二聚化。
6. Transmembrane helix heterodimerization in lipid bilayers: probing the energetics behind autosomal dominant growth disorders [O] . Mikhail Merzlyakov, Min You, Edwin Li, -1

机译：脂质双层中的跨膜螺旋异二聚化：探索常染色体显性生长障碍背后的能量学
7. Transmembrane Helix Heterodimerization in Lipid Bilayers: Probing the Energetics behind Autosomal Dominant Growth Disorders [O] . Mikhail Merzlyakov, Min You, Edwin Li, 2006

机译：脂质双层的跨膜螺旋异二聚化：探测常染色体显性增长障碍后的能量学

Transmembrane helix heterodimerization in lipid bilayers: Probing the energetics behind autosomal dominant growth disorders

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