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Tandem adaptation with a common design in Escherichia coli chemotaxis

机译:在大肠杆菌趋化性中具有通用设计的串联适应

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We analyze a model for motor-level adaptation in Escherichia coli based upon the premise that clockwise (CW) and counter-clockwise (CCW) states have different preferred numbers of FliM subunits. We show that this model provides a simple mechanism for the recently observed motor-level adaptation, and it also explains the long-lasting puzzle on the thresholds observed when tethered cells are used to monitor responses to temporal ramps. We note that the motor-level adaptation has the same negativefeedback network design as the upstream receptor-level adaptation, and the tandem architecture of one control circuit followed by the other mitigates the effects of cell-to-cell variation and broadens the range of stimuli over which cells optimally respond.
机译:我们基于顺时针(CW)和逆时针(CCW)状态具有不同的FliM亚基首选数量的前提,分析了大肠杆菌中电机水平适应的模型。我们表明,该模型为最近观察到的运动水平适应提供了一种简单的机制,并且还解释了当使用拴系细胞监测时间斜率的响应时所观察到的阈值存在的长期难题。我们注意到,电机水平适应具有与上游受体水平适应相同的负反馈网络设计,并且一个控制电路的串联结构随后是另一个控制电路减轻了细胞间变化的影响并扩大了刺激范围哪些细胞可以最佳反应。

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