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首页> 外文期刊>Journal of Molecular Biology >From the replicon to replication programs in space and time: Regulation of DNA replication and implications for genomic instability
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From the replicon to replication programs in space and time: Regulation of DNA replication and implications for genomic instability

机译：从复制子到复制程序的时空：DNA复制的调控及其对基因组不稳定性的影响

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This year marks the 50th anniversary of the presentation of the replicon theory at a Cold Spring Harbor Symposium by Frangois Jacob, Sydney Brenner, and Frangois Cuzin proposing a model to explain the regulation of DNA synthesis in bacteria and its coordination with the cell cycle and cell division at a time where there were still little experimental information on this mechanism [1]. The model proposed that DNA in bacteria is organized into autonomous units of replication each harboring a c/s-acting element (the replicator) and a frans-acting element (the structural gene for the initiator), whose interaction triggers replication initiation at the replicator (now called replication origin) and its collinear sequences that constitute the replicon. In this model, the initiator binds the replicator promote DNA unwinding, which allows the recruitment of the replication machinery. Replication forks progress bi-directionally from the replicators until replication of the circular bacterial chromosomes is complete.
机译：今年是Frangois Jacob，Sydney Brenner和Frangois Cuzin在冷泉港研讨会上提出复制子理论的50周年，提出了一个模型来解释细菌中DNA合成的调控及其与细胞周期和细胞的协调性。当时关于这种机制的实验信息仍然很少[1]。该模型提出细菌中的DNA被组织成复制的自主单元，每个单元都包含一个ac / s作用元件（复制子）和一个frans作用元件（引发剂的结构基因），它们的相互作用触发了复制子处的复制起始（现在称为复制原点）及其构成复制子的共线序列。在此模型中，启动子与复制子结合，促进DNA解链，从而允许复制机制的募集。复制叉从复制器双向进行，直到完成环形细菌染色体的复制。

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