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首页> 外文期刊>Journal of Molecular Biology >Regional Discrimination and Propagation of Local Rearrangements along the Ribosomal Exit Tunnel
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Regional Discrimination and Propagation of Local Rearrangements along the Ribosomal Exit Tunnel

机译：沿核糖体出口隧道的局部重排的区域歧视和传播

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摘要

All proteins, from bacteria to man, are made in the ribosome and are elongated, one residue at a time, at the peptidyl tranosferase center. This growing peptide chain wends its way through the ribosomal tunnel to the exit port, similar to 100 angstrom from the peptidyl transferase center. We have identified locations in the tunnel that sense and respond to single side chains of the nascent peptide to induce local conformational changes. Moreover, side-chain sterics and rearrangements deep in the tunnel influence the disposition of residues 45 angstrom away at the exit port and are consistent with side-chain-induced axial retraction of the peptide backbone. These coupled responses are neither haphazard nor uniform along the tunnel. Rather, they are confined to discriminating zones in the tunnel and are sequence specific. Such discerning communication may contribute to folding events and mechanisms governing sequence-specific signaling between different regions of the tunnel during translation. (C) 2014 Elsevier Ltd. All rights reserved.
机译：所有蛋白质，从细菌到人，都在核糖体中制造，并在肽基转铁酶中心一次被延长一个残基。这条增长的肽链穿过核糖体通道到达出口，类似于从肽基转移酶中心到100埃的通道。我们已经确定了隧道中感知并响应新生肽单侧链以诱导局部构象变化的位置。此外，隧道深处的侧链空间和重排影响出口处45埃处残基的位置，并与侧链诱导的肽骨架轴向缩回一致。这些耦合的响应既不是偶然的，也不是沿隧道统一的。相反，它们仅限于区分隧道中的区域，并且是特定于序列的。这种有区别的通信可能有助于折叠事件以及在翻译过程中控制隧道不同区域之间的序列特定信令的机制。 （C）2014 Elsevier Ltd.保留所有权利。

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