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首页> 外文期刊>Journal of Molecular Biology >Regional Discrimination and Propagation of Local Rearrangements along the Ribosomal Exit Tunnel
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Regional Discrimination and Propagation of Local Rearrangements along the Ribosomal Exit Tunnel

机译：核糖体出口隧道局部重排的区域歧视和繁殖

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摘要

All proteins, from bacteria to man, are made in the ribosome and are elongated, one residue at a time, at the peptidyl tranosferase center. This growing peptide chain wends its way through the ribosomal tunnel to the exit port, similar to 100 angstrom from the peptidyl transferase center. We have identified locations in the tunnel that sense and respond to single side chains of the nascent peptide to induce local conformational changes. Moreover, side-chain sterics and rearrangements deep in the tunnel influence the disposition of residues 45 angstrom away at the exit port and are consistent with side-chain-induced axial retraction of the peptide backbone. These coupled responses are neither haphazard nor uniform along the tunnel. Rather, they are confined to discriminating zones in the tunnel and are sequence specific. Such discerning communication may contribute to folding events and mechanisms governing sequence-specific signaling between different regions of the tunnel during translation. (C) 2014 Elsevier Ltd. All rights reserved.
机译：从细菌到人的所有蛋白质在核糖体中制备，并在肽基转移酶中心时伸长一个残余物。这种生长的肽链通过核糖体隧道到出口端口，与肽基转移酶中心类似于100埃。我们已经确定了隧道中的位置，感知并响应新生肽的单侧链以诱导局部构象变化。此外，隧道中深度的侧链静脉和重排部影响了在出口端口处的残留物45埃的布置，并且与肽骨架的侧链诱导的轴向缩回一致。这些耦合响应既不偶尔也不是隧道的均匀。相反，它们被限制在隧道中的区分区域，并且是特定的序列。这种辨别通信可以有助于折叠在翻译期间隧道的不同区域之间的序列特定信令的折叠事件和机制。 （c）2014年elestvier有限公司保留所有权利。

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