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首页> 外文期刊>Journal of Molecular Biology >The operon as paradigm: normal science and the beginning of biological complexity.
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The operon as paradigm: normal science and the beginning of biological complexity.

机译：操纵子作为范例：普通科学和生物学复杂性的开始。

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The papers from the Jacob and Monod groups that presented the operon model and repressor control of gene expression provided a paradigm that opened up the field of gene regulation. Following the set of papers published between 1958 and 1961, there ensued almost immediately a period of "normal science" as Thomas Kuhn has defined it. Most researchers applied the repressor model to their own systems. I suggest a number of factors that were responsible for the rapid acceptance of the Jacob-Monod model and inhibited suggestions for alternative mechanisms of regulation. Nevertheless, I argue that this adherence to the paradigm, including specifically control by repressors, may well have been necessary for the field to progress. Ultimately, the evolution of this field of study was to reveal the unexpected complexity to genetic regulation.
机译：雅各布和莫诺德小组的论文介绍了操纵子模型和基因表达的阻遏物控制，提供了打开基因调控领域的范例。继1958年至1961年发表的那一系列论文之后，托马斯·库恩（Thomas Kuhn）对其进行了定义，此后几乎随即出现了一个“正常科学”时期。大多数研究人员将阻遏物模型应用于他们自己的系统。我提出了导致快速接受Jacob-Monod模型的许多因素，并抑制了其他调节机制的建议。尽管如此，我认为这种坚持范式，包括具体地由阻遏物控制可能是该领域发展所必需的。最终，该研究领域的演变是揭示基因调控的意想不到的复杂性。

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