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The design of an enzyme: A chronology on the controversy

机译:酶的设计:争议年表

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After the publication of the Monod-Wyman-Changeux model, a controversy arose between Jacques Monod, Francis Crick and Jeffries Wyman about the comparison of the regulatory performances of an oligomer undergoing a concerted transition between two states and a monomer having the same composition and subjected to a similar conformational equilibrium. The controversy took place between September 1965 and March 1966. It gave rise to several unpublished notes. Numerous misunderstandings between the participants were not fully dissipated as the controversy abruptly ended.
机译:在Monod-Wyman-Changeux模型发布后,雅克·莫诺德(Jacques Monod),弗朗西斯·克里克(Francis Crick)和杰弗里斯·怀曼(Jeffries Wyman)之间引发了一场争论,涉及比较低聚物在两种状态下的协同性能与具有相同组成并经受相同作用的单体之间的调节性能的比较达到类似的构象平衡。争议发生在1965年9月至1966年3月之间。它引起了一些未发表的笔记。由于争议突然结束,参与者之间的许多误解未能完全消除。

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