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Nuclear Organization Changes and the Epigenetic Silencing of FLC during Vernalization

机译：春化过程中FLC的核组织变化和表观遗传沉默

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摘要

Changes in nuclear organization are considered an important complement to trans-acting factors, histone modifications and non-coding RNAs in robust and stable epigenetic silencing. However, how these multiple layers interconnect mechanistically to reinforce each other's activity is still unclear. A system providing long timescales facilitating analysis of these interconnections is vernalization. This involves the Polycomb-mediated epigenetic silencing of flowering locus C (FLC) that occurs as Arabidopsis plants are exposed to prolonged cold. Analysis of changes in nuclear organization during vernalization has revealed that disruption of a gene loop and physical clustering of FLC loci are part of the vernalization mechanism. These events occur at different times and thus contribute to distinct aspects of the silencing mechanism. The physical clustering of FLC loci is tightly correlated with the accumulation of specific Polycomb complexes/H3K27me3 at a localized intragenic site during the cold. Since the quantitative nature of vernalization is a reflection of a bistable cell autonomous switch in an increasing number of cells, this correlation suggests a tight connection between the switching mechanism and changes in nuclear organization. This integrated picture is likely to be informative for many epigenetic mechanisms. (c) 2014 The Authors. Published by Elsevier Ltd.
机译：在健壮和稳定的表观遗传沉默中，核组织的变化被认为是反式作用因子，组蛋白修饰和非编码RNA的重要补充。但是，这些多层如何机械地相互连接以增强彼此的活动仍不清楚。提供长时标以促进对这些互连的分析的系统是春化。这涉及到拟南芥植物暴露于长时间的寒冷中时，Polycomb介导的开花基因座C（FLC）的表观遗传沉默。春化过程中核组织变化的分析表明，基因环的破坏和FLC基因座的物理聚类是春化机制的一部分。这些事件发生在不同的时间，因此有助于沉默机制的各个方面。 FLC基因座的物理聚类与特定的Polycomb复合体/ H3K27me3在寒冷期间在本地基因内位点的积累紧密相关。由于春化的定量性质反映了越来越多的细胞中双稳态细胞自主开关的发生，因此这种相关性暗示了开关机制与核组织变化之间的紧密联系。这一综合图景可能会为许多表观遗传机制提供参考。 （c）2014作者。由Elsevier Ltd.发布

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