• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Molecular Biology >Nuclear Organization Changes and the Epigenetic Silencing of FLC during Vernalization
【24h】

Nuclear Organization Changes and the Epigenetic Silencing of FLC during Vernalization

机译：核组织在春节化期间变化和FLC的表观遗传沉默

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Changes in nuclear organization are considered an important complement to trans-acting factors, histone modifications and non-coding RNAs in robust and stable epigenetic silencing. However, how these multiple layers interconnect mechanistically to reinforce each other's activity is still unclear. A system providing long timescales facilitating analysis of these interconnections is vernalization. This involves the Polycomb-mediated epigenetic silencing of flowering locus C (FLC) that occurs as Arabidopsis plants are exposed to prolonged cold. Analysis of changes in nuclear organization during vernalization has revealed that disruption of a gene loop and physical clustering of FLC loci are part of the vernalization mechanism. These events occur at different times and thus contribute to distinct aspects of the silencing mechanism. The physical clustering of FLC loci is tightly correlated with the accumulation of specific Polycomb complexes/H3K27me3 at a localized intragenic site during the cold. Since the quantitative nature of vernalization is a reflection of a bistable cell autonomous switch in an increasing number of cells, this correlation suggests a tight connection between the switching mechanism and changes in nuclear organization. This integrated picture is likely to be informative for many epigenetic mechanisms. (c) 2014 The Authors. Published by Elsevier Ltd.
机译：核组织的变化被认为是易行因子，组蛋白修饰和稳健性的表观遗传沉默中的组蛋白修饰和非编码RNA的重要补充。然而，这些多层如何机械地互连以加强彼此的活动仍然不清楚。提供长时间的系统促进这些互连的分析是vernalization。这涉及用作拟南芥植物暴露于延长寒冷的开花基因座C（FLC）的PolycomB介导的外形沉默。春化期间核组织变化分析揭示了FLC基因座的基因环路和物理聚类的破坏是春化机制的一部分。这些事件发生在不同的时间，从而有助于沉默机制的独特方面。 FLC基因座的物理聚类与在寒冷期间局部血压位点的特定Polycomb复合物/ H3K27ME3的积累紧密相关。由于诸如vernalization的定量性质是在越来越多的电池中的双稳态细胞自主开关的反射，因此这种相关性表明了切换机构与核组织的变化之间的紧密连接。这种综合图片可能是许多表观遗传机制的信息。 （c）2014年作者。 elsevier有限公司出版

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号