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首页> 外文期刊>Journal of Molecular Biology >Bacterial Voltage-Gated Sodium Channels (BacNa(V)s) from the Soil, Sea, and Salt Lakes Enlighten Molecular Mechanisms of Electrical Signaling and Pharmacology in the Brain and Heart
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Bacterial Voltage-Gated Sodium Channels (BacNa(V)s) from the Soil, Sea, and Salt Lakes Enlighten Molecular Mechanisms of Electrical Signaling and Pharmacology in the Brain and Heart

机译：来自土壤，海洋和盐湖的细菌电压门控钠通道（BacNa（V）s）启发了脑和心脏中电信号传导和药理学的分子机制

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摘要

Voltage-gated sodium channels (Na(V)s) provide the initial electrical signal that drives action potential generation in many excitable cells of the brain, heart, and nervous system. For more than 60 years, functional studies of Nays have occupied a central place in physiological and biophysical investigation of the molecular basis of excitability. Recently, structural studies of members of a large family of bacterial voltage-gated sodium channels (BacNa(V)s) prevalent in soil, marine, and salt lake environments that bear many of the core features of eukaryotic Nays have reframed ideas for voltage-gated channel function, ion selectivity, and pharmacology. Here, we analyze the recent advances, unanswered questions, and potential of BacNa(V)s as templates for drug development efforts. (C) 2014 The Authors. Published by Elsevier Ltd.
机译：电压门控钠通道（Na（V）s）提供初始电信号，该信号驱动大脑，心脏和神经系统的许多可兴奋细胞中动作电位的产生。 60多年来，Nays的功能研究已在兴奋性分子基础的生理和生物物理研究中占据中心位置。最近，对细菌，电压门控钠通道（BacNa（V））家族的广泛结构进行研究，这些通道普遍存在于具有真核Nays核心特征的土壤，海洋和盐湖环境中。门控通道功能，离子选择性和药理学。在这里，我们分析BacNa（V）作为药物开发工作模板的最新进展，未解决的问题以及潜力。 （C）2014作者。由Elsevier Ltd.发布

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