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首页> 外文期刊>Journal of Non-Crystalline Solids: A Journal Devoted to Oxide, Halide, Chalcogenide and Metallic Glasses, Amorphous Semiconductors, Non-Crystalline Films, Glass-Ceramics and Glassy Composites >Collagen/fibrin microbeads as a delivery system for Ag-doped bioactive glass and DPSCs for potential applications in dentistry
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Collagen/fibrin microbeads as a delivery system for Ag-doped bioactive glass and DPSCs for potential applications in dentistry

机译：胶原蛋白/纤维蛋白微珠作为掺银生物活性玻璃和DPSC的递送系统，可在牙科中潜在应用

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Silver doped bioactive glass (Ag-BG) and Dental Pulp Stem Cells (DPSCs) have shown promising properties for dental tissue regeneration. This study presents the fabrication and characterization of composite collagen/fibrin microbeads that aimed to incorporate and successfully deliver both Ag-BG and DPSC Cell viability, cell differentiation in vitro and in vivo, and antibacterial properties of the systems against Escherichia coli (E. coli), Streptococcus mutans (S. mutans) and Enterococcus faecalis (E. faecalis) were evaluated. Cell viability and proliferation of DPSCs within the delivery system were found unaltered in both combinations (Beads/DPSCs and Beads/DPSCs/Ag-BG). Our results show that Ag-BG and DPSCs were successfully incorporated and proliferated within the collagen/fibrin microbeads. DPSCs continued to proliferate up to 6-weeks in cell culture but cell differentiation into odontoblast-like cells was observed only in vivo. The beads containing Ag-BG strongly inhibit bacterial growth in the experimental groups (beads alone, Beads/Ag-BG and Beads/DPSCs/Ag-BG). Our data suggests that collagen/fibrin microbead paste could have clinical applicability in the regenerative dentistry field. (C) 2015 Elsevier B.V. All rights reserved.
机译：掺杂银的生物活性玻璃（Ag-BG）和牙髓干细胞（DPSC）已显示出具有前景的牙科组织再生特性。这项研究提出了合成胶原蛋白/纤维蛋白微珠的制备和表征，旨在掺入并成功交付Ag-BG和DPSC细胞活力，体内和体外细胞分化以及该系统对大肠杆菌（E. coli）的抗菌特性），变形链球菌（S. mutans）和粪肠球菌（E. faecalis）进行了评估。两种组合（珠子/ DPSC和珠子/ DPSCs / Ag-BG）的细胞存活力和递送系统中DPSC的增殖均未改变。我们的结果表明，Ag-BG和DPSCs已成功掺入并在胶原蛋白/纤维蛋白微珠中增殖。 DPSC在细胞培养中持续增殖长达6周，但仅在体内观察到细胞分化为成牙本质细胞样细胞。在实验组中，含Ag-BG的珠子强烈抑制细菌生长（单独的珠子，Beads / Ag-BG和Beads / DPSCs / Ag-BG）。我们的数据表明，胶原蛋白/纤维蛋白微珠糊剂在再生牙科领域可能具有临床适用性。 （C）2015 Elsevier B.V.保留所有权利。

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