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首页> 外文期刊>Journal of Neurophysiology >Activation of beta-noradrenergic receptors enhances rhythmic bursting in mouse olfactory bulb external tufted cells
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Activation of beta-noradrenergic receptors enhances rhythmic bursting in mouse olfactory bulb external tufted cells

机译：β-去甲肾上腺素能受体的激活增强了小鼠嗅球外簇状细胞的节律性爆发

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摘要

The main olfactory bulb (MOB) receives a rich noradrenergic innervation from the nucleus locus coeruleus. Despite the well-documented role of norepinephrine and beta-adrenergic receptors in neonatal odor preference learning, identified cellular physiological actions of beta-receptors in the MOB have remained elusive. beta-Receptors are expressed at relatively high levels in the MOB glomeruli, the location of external tufted (ET) cells that exert an excitatory drive on mitral and other cell types. The present study investigated the effects of beta-receptor activation on the excitability of ET cells with patch-clamp electrophysiology in mature mouse MOB slices. Isoproterenol and selective beta(2)-, but not beta(1)-, receptor agonists were found to enhance two key intrinsic currents involved in ET burst initiation: persistent sodium (I-NaP) and hyperpolarization-activated inward (I-h) currents. Together, the positive modulation of these currents increased the frequency and strength of ET cell rhythmic bursting. Rodent sniff frequency and locus coeruleus neuronal firing increase in response to novel stimuli or environments. The increase in ET excitability by beta-receptor activation may better enable ET cell rhythmic bursting, and hence glomerular network activity, to pace faster sniff rates during heightened norepinephrine release associated with arousal.
机译：主嗅球（MOB）从蓝斑核中吸收了丰富的去甲肾上腺素能。尽管去甲肾上腺素和β-肾上腺素能受体在新生儿气味偏好学习中的作用已有充分文献记载，但已确定的MOB中β受体的细胞生理作用仍然难以捉摸。 β受体在MOB肾小球中相对较高的水平表达，这是对二尖瓣和其他细胞类型施加兴奋性驱动的外部簇状（ET）细胞的位置。本研究调查了β受体活化对成熟小鼠MOB切片中膜片钳电生理学对ET细胞兴奋性的影响。发现异丙肾上腺素和选择性β（2）-，但不是β（1）-受体激动剂可增强参与ET爆发起始的两个关键内在电流：持续钠（I-NaP）和超极化激活的内向（I-h）电流。总之，这些电流的正调制增加了ET细胞节律性爆发的频率和强度。啮齿动物的嗅闻频率和蓝斑蓝斑神经元放电响应新的刺激或环境而增加。通过β受体激活而增加的ET兴奋性可能使ET细胞的节律性爆发以及肾小球网络活动能够更好地加快与唤醒相关的去甲肾上腺素释放期间的嗅闻速率。

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