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Properties of VIP plus synapses in the suprachiasmatic nucleus highlight their role in circadian rhythm

机译:视交叉上核VIP加突触的特性突出了它们在昼夜节律中的作用

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摘要

Circadian rhythms coordinate cyclical behavioral and physiological changes in most organisms. In humans, this biological clock is located within the suprachiasmatic nucleus (SCN) of the hypothalamus and consists of a heterogeneous neuron population characterized by their enriched expression of various neuropeptides. As highlighted here, Fan et al. (J Neurosci 35: 1905-1029, 2015) developed an elegant experimental system to investigate the synaptic properties of vasoactive intestinal peptide (VIP)-expressing neurons between day and night, and further delineate their broader architecture and function within the SCN.
机译:昼夜节律协调大多数生物体的周期性行为和生理变化。在人类中,该生物钟位于下丘脑的上睑眼上核(SCN)内,由异质神经元群体组成,其特征在于它们丰富地表达了各种神经肽。如此处突出显示的,Fan等。 (J Neurosci 35:1905-1029,2015)开发了一个优雅的实验系统来研究表达血管活性肠肽(VIP)的神经元在白天和黑夜之间的突触特性,并进一步描述它们在SCN中的更广泛的结构和功能。

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