...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neurophysiology >L-type calcium channels refine the neural population code of sound level
【24h】

L-type calcium channels refine the neural population code of sound level

机译：L型钙通道完善了声级的神经人口代码

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The coding of sound level by ensembles of neurons improves the accuracy with which listeners identify how loud a sound is. In the auditory system, the rate at which neurons fire in response to changes in sound level is shaped by local networks. Voltage-gated conductances alter local output by regulating neuronal firing, but their role in modulating responses to sound level is unclear. We tested the effects of L-type calcium channels (Ca-L : Ca(V)1.1-1.4) on sound-level coding in the central nucleus of the inferior colliculus (ICC) in the auditory midbrain. We characterized the contribution of Ca-L to the total calcium current in brain slices and then examined its effects on rate-level functions (RLFs) in vivo using single-unit recordings in awake mice. Ca-L is a high-threshold current and comprises similar to 50% of the total calcium current in ICC neurons. In vivo, Ca-L activates at sound levels that evoke high firing rates. In RLFs that increase monotonically with sound level, Ca-L boosts spike rates at high sound levels and increases the maximum firing rate achieved. In different populations of RLFs that change nonmonotonically with sound level, Ca-L either suppresses or enhances firing at sound levels that evoke maximum firing. Ca-L multiplies the gain of monotonic RLFs with dynamic range and divides the gain of nonmonotonic RLFs with the width of the RLF. These results suggest that a single broad class of calcium channels activates enhancing and suppressing local circuits to regulate the sensitivity of neuronal populations to sound level.
机译：通过神经元集合对声级进行编码，可以提高听众识别声音有多响的准确性。在听觉系统中，神经元响应于声级变化而激发的速率由本地网络决定。电压门控电导通过调节神经元放电来改变局部输出，但是它们在调节对声级的响应中的作用尚不清楚。我们测试了L型钙通道（Ca-L：Ca（V）1.1-1.4）对听觉中脑下丘脑（ICC）中央核的声级编码的影响。我们表征了Ca-L对脑切片中总钙电流的贡献，然后使用清醒小鼠中的单单位记录检查了其对体内速率水平功能（RLFs）的影响。 Ca-L是高阈值电流，占ICC神经元总钙电流的50％左右。在体内，Ca-L的激活能激发高发射速率。在随声级单调增加的RLF中，Ca-L可以提高高声级时的尖峰率，并提高所达到的最大发射率。在随声级非单调变化的不同RLF群体中，Ca-L抑制或增强了引起最大发射的声级发射。 Ca-L将单调RLF的增益与动态范围相乘，并将非单调RLF的增益除以RLF的宽度。这些结果表明，单一种类的钙通道可激活增强和抑制局部回路，从而调节神经元群体对声音水平的敏感性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号