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首页> 外文期刊>Journal of Neurophysiology >Single-trial decoding of intended eye movement goals from lateral prefrontal cortex neural ensembles
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Single-trial decoding of intended eye movement goals from lateral prefrontal cortex neural ensembles

机译：从外侧前额叶皮层神经组合对眼睛预期运动目标进行单次解码

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摘要

Neurons in the lateral prefrontal cortex (LPFC) encode sensory and cognitive signals, as well as commands for goal-directed actions. Therefore, the LPFC might be a good signal source for a goal-selection brain-computer interface (BCI) that decodes the intended goal of a motor action previous to its execution. As a first step in the development of a goal-selection BCI, we set out to determine if we could decode simple behavioral intentions to direct gaze to eight different locations in space from single-trial LPFC neural activity. We recorded neuronal spiking activity from microelectrode arrays implanted in area 8A of the LPFC of two adult macaques while they made visually guided saccades to one of eight targets in a center-out task. Neuronal activity encoded target location immediately after target presentation, during a delay epoch, during the execution of the saccade, and every combination thereof. Many (40%) of the neurons that encoded target location during multiple epochs preferred different locations during different epochs. Despite heterogeneous and dynamic responses, the neuronal feature set that best predicted target location was the averaged firing rates from the entire trial and it was best classified using linear discriminant analysis (63.6-96.9% in 12 sessions, mean 80.3%; information transfer rate: 21-59, mean 32.8 bits/min). Our results demonstrate that it is possible to decode intended saccade target location from single-trial LPFC activity and suggest that the LPFC is a suitable signal source for a goal-selection cognitive BCI.
机译：前额外侧皮层（LPFC）中的神经元编码感觉和认知信号，以及针对目标的动作的命令。因此，LPFC可能是目标选择脑机接口（BCI）的良好信号源，该接口可在执行动作之前解码运动动作的预期目标。作为开发目标选择BCI的第一步，我们着手确定是否可以解码简单的行为意图，以将单视LPFC神经活动引导至太空中的八个不同位置。我们记录了植入两个成年猕猴的LPFC区域8A中的微电极阵列的神经元突刺活动，而他们将视觉引导的扫视运动瞄准了中心任务中的八个目标之一。神经元活动在目标呈现之后，延迟时期，扫视执行期间以及它们的每种组合之后立即编码目标位置。在多个时期内编码目标位置的神经元中有许多（40％）会在不同时期内选择不同的位置。尽管存在异质和动态响应，但神经元特征集认为最佳预测目标位置是整个试验的平均放电率，并且最好使用线性判别分析对其进行分类（在12个疗程中为63.6-96.9％，平均80.3％;信息传递率： 21-59，平均32.8位/分钟）。我们的结果表明，有可能从单次LPFC活动中解码预期的扫视目标位置，并表明LPFC是目标选择认知BCI的合适信号源。

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