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首页> 外文期刊>Journal of Neurophysiology >Botulinum toxin injection causes hyper-reflexia and increased muscle stiffness of the triceps surae muscle in the rat
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Botulinum toxin injection causes hyper-reflexia and increased muscle stiffness of the triceps surae muscle in the rat

机译：注射肉毒杆菌毒素会引起大鼠反射亢进并增加肱三头肌肱三头肌的肌肉僵硬

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Botulinum toxin is used with the intention of diminishing spasticity and reducing the risk of development of contractures. Here, we investigated changes in muscle stiffness caused by reflex activity or elastic muscle properties following botulinum toxin injection in the triceps surae muscle in rats. Forty-four rats received injection of botulinum toxin in the left triceps surae muscle. Control measurements were performed on the noninjected contralateral side in all rats. Acute experiments were performed, 1, 2, 4, and 8 wk following injection. The triceps surae muscle was dissected free, and the Achilles tendon was cut and attached to a muscle puller. The resistance of the muscle to stretches of different amplitudes and velocities was systematically investigated. Reflex-mediated torque was normalized to the maximal muscle force evoked by supramaximal stimulation of the tibial nerve. Botulinum toxin injection caused severe atrophy of the triceps surae muscle at all time points. The force generated by stretch reflex activity was also strongly diminished but not to the same extent as the maximal muscle force at 2 and 4 wk, signifying a relative reflex hyperexcitability. Passive muscle stiffness was unaltered at 1 wk but increased at 2, 4, and 8 wk (P < 0.01). These data demonstrate that botulinum toxin causes a relative increase in reflex stiffness, which is likely caused by compensatory neuroplastic changes. The stiffness of elastic elements in the muscles also increased. The data are not consistent with the ideas that botulinum toxin is an efficient antispastic medication or that it may prevent development of contractures.
机译：肉毒杆菌毒素的用途是减少痉挛并减少挛缩的风险。在这里，我们调查了在大鼠肱三头肌肱三头肌中注射肉毒杆菌毒素后由反射活动或弹性肌肉特性引起的肌肉僵硬变化。 44只大鼠在左肱三头肌腓肠肌注射了肉毒杆菌毒素。在所有大鼠的非注射对侧进行对照测量。注射后1、2、4和8周进行急性实验。游离切开肱三头肌肌肉，并切断跟腱，并固定在拉马器上。系统地研究了肌肉对不同幅度和速度的拉伸的抵抗力。反射介导的扭矩被标准化为胫神经最大刺激所引起的最大肌肉力。肉毒杆菌毒素注射在所有时间点都导致腓肠肌三头肌严重萎缩。拉伸反射活动产生的力也大大降低，但幅度不超过2和4 wk时的最大肌肉力，这表示相对反射过度兴奋。被动肌肉的刚度在1周时不变，但在2、4和8周时增加（P <0.01）。这些数据表明肉毒杆菌毒素会导致反射刚度相对增加，这很可能是由代偿性神经增生性变化引起的。肌肉中弹性元件的刚度也增加了。数据与肉毒杆菌毒素是有效的抗痉挛药或可能预防挛缩发展的观点不一致。

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