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首页> 外文期刊>Journal of Physics, D. Applied Physics: A Europhysics Journal >Intraluminal bubble dynamics induced by lithotripsy shock wave
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Intraluminal bubble dynamics induced by lithotripsy shock wave

机译：碎石冲击波引起的腔内气泡动力学

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摘要

Extracorporeal shock wave lithotripsy (ESWL) has been the first option in the treatment of calculi in the upper urinary tract since its introduction. ESWL-induced renal injury is also found after treatment and is assumed to associate with intraluminal bubble dynamics. To further understand the interaction of bubble expansion and collapse with the vessel wall, the finite element method (FEM) was used to simulate intraluminal bubble dynamics and calculate the distribution of stress in the vessel wall and surrounding soft tissue during cavitation. The effects of peak pressure, vessel size, and stiffness of soft tissue were investigated. Significant dilation on the vessel wall occurs after contacting with rapid and large bubble expansion, and then vessel deformation propagates in the axial direction. During bubble collapse, large shear stress is found to be applied to the vessel wall at a clinical lithotripter setting (i.e. 40 MPa peak pressure), which may be the mechanism of ESWL-induced vessel rupture. The decrease of vessel size and viscosity of soft tissue would enhance vessel deformation and, consequently, increase the generated shear stress and normal stresses. Meanwhile, a significantly asymmetric bubble boundary is also found due to faster axial bubble expansion and shrinkage than in radial direction, and deformation of the vessel wall may result in the formation of microjets in the axial direction. Therefore, this numerical work would illustrate the mechanism of ESWLinduced tissue injury in order to develop appropriate counteractive strategies for reduced adverse effects.
机译：自引进以来，体外冲击波碎石术（ESWL）一直是治疗上尿路结石的首选方法。在治疗后也发现了ESWL引起的肾损伤，并被认为与管腔内气泡动力学有关。为了进一步了解气泡膨胀和破裂与血管壁的相互作用，有限元方法（FEM）用于模拟腔内气泡动力学并计算空化过程中血管壁和周围软组织的应力分布。研究了峰值压力，血管大小和软组织硬度的影响。在与快速且大的气泡膨胀接触之后，在血管壁上发生明显的膨胀，然后血管变形沿轴向传播。在气泡破裂过程中，发现在临床碎石机设置（即40 MPa峰值压力）下会向血管壁施加较大的剪切应力，这可能是ESWL诱发血管破裂的机制。血管尺寸和软组织粘度的减小将增强血管变形，并因此增加所产生的剪切应力和法向应力。同时，由于比轴向上更快的轴向气泡膨胀和收缩，还发现了明显不对称的气泡边界，并且容器壁的变形可能导致在轴向上形成微射流。因此，该数字工作将说明ESWL诱导的组织损伤的机制，以便开发出适当的反作用策略以减少不良反应。

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