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Clinical and forensic signs related to cocaine abuse

机译：与可卡因滥用有关的临床和法医症状

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Good laboratory practice in toxicological analysis requires pre-analytical steps for collection of detailed information related to the suspected poisoning episodes, including biological and non-biological circumstantial evidences, which should be carefully scrutinized. This procedure provides great help to unveil the suspected cause of poisoning, to select the appropriate and correct samples to be analyzed and can facilitate the decision about the analytical techniques to perform. This implies a good knowledge of the signs related to acute and chronic intoxications by drugs of abuse. In this manuscript we highlight and discuss clinical and forensic imaging related to cocaine abuse, namely the midline destructive lesion, dental health, pseudoscleradermatous triad and crack hands, necrosis and gangrene of extremities and several other skin manifestations, reticular purpura, intracerebral and peripheral hemorrhages, angioneurotic edema, rhabdomyolysis, and crack lung. For this purpose, the state of the art on this topic is discussed, using clinical and forensic cases from our professional database in complement to images and mechanistic data from literature.
机译：毒理学分析中的良好实验室操作要求采取分析前步骤，以收集与可疑中毒事件有关的详细信息，包括生物学和非生物学的间接证据，应仔细检查这些证据。该程序为揭露可疑的中毒原因，选择适当和正确的样品进行分析提供了很大的帮助，并且可以帮助您确定要执行的分析技术。这意味着对与滥用药物引起的急性和慢性中毒有关的体征有充分的了解。在本手稿中，我们重点介绍并讨论了与可卡因滥用有关的临床和法医成像，即中线破坏性病变，牙齿健康，假性巩膜瘤三联症和手部骨折，四肢坏死和坏疽以及其他几种皮肤表现，网状紫癜，脑内和周围出血，血管神经性水肿，横纹肌溶解和肺裂。为此，我们使用来自我们专业数据库的临床和法医案例，对文献中的图像和机械数据进行补充，讨论了有关此主题的最新技术。

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