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Synthetic Cannabinoids as drugs of abuse

机译：合成大麻素被滥用

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摘要

In the last decade a number of products have appeared in various countries that contain synthetic cannabinoids. This article reviews the history of the sale of these drugs, and the evidence that they contain synthetic cannabinoids. The biochemistry of the synthetic cannabinoids identified thus far is discussed, including a discussion of chemical structures and biochemical targets. The cannabinoid receptor targets for these drugs are discussed, as well as other possible targets such as serotonin receptors. Evidence for the abuse potential of these drugs is reviewed. The toxicity of synthetic cannabinoids and cannabinoid products is reviewed and compared to that of the phytocannabinoid Δ9- tetrahydrocannabinol (THC). As cannabinoids are a structurally diverse class of drugs, it is concluded that synthetic cannabinoids should be classified by biological activity rather than by structure, and that if this isn't done, novel synthetic cannabinoids will continue to emerge that fall outside of current regulatory classification models.
机译：在过去的十年中，许多产品出现在各个国家，这些产品都含有合成大麻素。本文回顾了这些药物的销售历史，以及它们含有合成大麻素的证据。讨论了迄今为止确定的合成大麻素的生物化学，包括化学结构和生物化学目标的讨论。讨论了这些药物的大麻素受体靶标，以及其他可能的靶标，例如5-羟色胺受体。审查了这些药物潜在滥用的证据。综述了合成大麻素和大麻素产品的毒性，并将其与植物大麻素Δ9-四氢大麻酚（THC）的毒性进行了比较。由于大麻素是结构上多样化的药物，因此可以得出结论，合成大麻素应按生物学活性而不是结构进行分类，并且如果不这样做，则新的合成大麻素将继续出现，而目前的监管分类除外楷模。

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