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首页> 外文期刊>Current opinion in endocrinology, diabetes, and obesity >Developmental programming and adult obesity: the role of leptin.
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Developmental programming and adult obesity: the role of leptin.

机译：发育性编程和成人肥胖：瘦素的作用。

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PURPOSE OF REVIEW: An adverse prenatal environment may induce long-term metabolic consequences, in particular obesity and insulin resistance. Although the mechanisms are unclear, this 'programming' has generally been considered an irreversible change in developmental trajectory. Recent work has highlighted the importance of the hormone leptin during critical windows of development in the pathogenesis of programming related disorders. RECENT FINDINGS: Maintaining a critical leptin level during development may allow the normal maturation of tissues and pathways involved in metabolic homeostasis and a period of relative hypo or hyperleptinemia may induce some of the metabolic adaptations which underlie developmental programming. Furthermore, nutritional or therapeutic intervention in postnatal life can ameliorate the consequences of developmental malprogramming and, at least in the rodent, developmental programming is potentially reversible by intervention with leptin late in the phase of developmental plasticity. SUMMARY: Inappropriate growth during pregnancy or lactation can result in individuals with an increased risk of later obesity and related metabolic sequelae. Taken together, recent studies highlight the importance of leptin in disorders manifest as a consequence of developmental programming and offer exciting new strategies for therapeutic intervention, whether it be maternal or neonatal intervention or targeted nutritional manipulation in postnatal life.
机译：审查目的：不利的产前环境可能会引起长期的代谢后果，特别是肥胖和胰岛素抵抗。尽管机制尚不清楚，但是这种“编程”通常被认为是发展轨迹的不可逆转的变化。最近的工作已经强调了激素瘦素在编程相关疾病的发病机理的关键发展期中的重要性。最近的发现：在发育过程中维持关键的瘦素水平可以使参与代谢稳态的组织和途径正常成熟，相对低血脂或高瘦素血症的一段时间可能会诱发一些代谢适应，这是发育程序的基础。此外，产后生活中的营养或治疗干预可以改善发育不良的后果，并且至少在啮齿动物中，在发育可塑性阶段后期进行的瘦素干预有可能逆转发育计划。摘要：怀孕或哺乳期间不适当的生长会导致个体后来肥胖和相关代谢后遗症的风险增加。综上，最近的研究强调了瘦素在疾病中的重要性，这是发展计划的结果，并为治疗干预提供了令人兴奋的新策略，无论是母体干预或新生儿干预，还是产后生活中的定向营养操作。

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