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首页> 外文期刊>Current opinion in endocrinology, diabetes, and obesity >Temporal trends in testosterone levels and treatment in older men.
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Temporal trends in testosterone levels and treatment in older men.

机译：老年男性睾丸激素水平和治疗的时间趋势。

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摘要

PURPOSE OF REVIEW: Longitudinal studies of testosterone concentrations have yielded sharper estimates of age-related androgen declines than their cross-sectional counterparts. A potential explanation for this phenomenon is a secular (age independent) mechanism acting to accelerate within-individual testosterone decreases with time. This article reviews the evidence in favor of such secular trends and discusses potential causes and implications. RECENT FINDINGS: The magnitude of the proposed secular trend may be as much as 1% per calendar year in excess of per year cross-sectional trends. Current evidence suggests that body composition changes as expressed by BMI can in part account for the trend in testosterone. More speculative recent findings suggest a potential contributory role for environmental endocrine disruptors, but to date no longitudinal studies have examined this question. Symptomatic androgen deficiency as currently defined is associated with diverse downstream morbidity, but may not constitute a robust designation over longer term periods of time. Information concerning treatment patterns in the general population is limited. SUMMARY: Existing evidence, though limited, supports the hypothesis of secular declines in serum testosterone levels in adult men. It is conceivable that these trends may influence the health of the public. Studies confirming and accounting for these trends are needed.
机译：审查目的：睾丸激素浓度的纵向研究得出了与年龄相关的雄激素下降的更清晰的估计。这种现象的潜在解释是世俗的（年龄独立的）机制，其作用是促进个体内睾丸激素随时间而减少。本文回顾了支持这种长期趋势的证据，并讨论了潜在的原因和影响。最近的发现：建议的长期趋势的幅度可能超过每年横截面趋势，每年超过1％。目前的证据表明，由BMI表示的身体成分变化可以部分解释睾丸激素的趋势。最近的更多投机性发现提示环境内分泌干扰物可能起了促进作用，但迄今为止，尚无纵向研究研究此问题。当前定义的有症状雄激素缺乏症与多种下游发病率有关，但在较长时期内可能并不构成可靠的标志。有关普通人群治疗方式的信息有限。摘要：现有证据尽管有限，但支持成年男性血清睾丸激素水平长期下降的假说。可以想象，这些趋势可能会影响公众的健康。需要进行研究以确认和解释这些趋势。

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