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首页> 外文期刊>Current opinion in endocrinology, diabetes, and obesity >The role of innate immune pathways in type 1 diabetes pathogenesis.
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The role of innate immune pathways in type 1 diabetes pathogenesis.

机译：先天性免疫途径在1型糖尿病发病机理中的作用。

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摘要

PURPOSE OF REVIEW: Type 1 diabetes (T1D) is an autoimmune disease typically believed to result from malfunctions in adaptive immune response signaling which result in activation of self-reactive T cells. However, recent research has indicated components of the innate immune response as having a key role in the initiation of the autoimmune process of T1D. This review will highlight recent studies which examined the role of innate immune response signaling and the connections to T1D pathogenesis. RECENT FINDINGS: Investigations indicate that components of innate immunity, including inflammation and Toll-like receptor signaling, are involved in pancreatic islet infiltration and insulitis. Recent studies examining the role of viral infections in T1D development also implicate innate immune response signaling in disease pathogenesis. SUMMARY: Current research indicates that components of innate immune response signaling are involved in the initiation of the autoimmune process which results in the eventual destruction of beta cells during T1D pathogenesis. Continuing efforts by researchers to uncover the molecular pathways of innate immunity linked to T1D development could potentially lead to therapeutics capable of preventing and curing the autoimmune disease.
机译：审查目的：1型糖尿病（T1D）是一种自身免疫性疾病，通常被认为是由于适应性免疫应答信号传导功能异常导致的，该功能异常导致自身反应性T细胞活化。但是，最近的研究表明，先天免疫应答的组成部分在T1D自身免疫过程的启动中具有关键作用。这篇综述将重点介绍最近的研究，这些研究检查了先天免疫应答信号传导的作用以及与T1D发病机制的联系。最新发现：研究表明，先天免疫的组成部分，包括炎症和Toll样受体信号传导，都参与了胰岛浸润和胰岛炎。最近研究研究了病毒感染在T1D发育中的作用，也暗示了在疾病发病机理中固有的免疫应答信号传导。简介：当前研究表明，固有免疫应答信号传导的成分参与自身免疫过程的启动，导致T1D发病机理中β细胞的最终破坏。研究人员继续努力发现与T1D发育有关的先天免疫的分子途径可能会导致能够预防和治愈自身免疫性疾病的疗法。

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