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首页> 外文期刊>Current opinion in clinical nutrition and metabolic care >Role of macrophage tissue infiltration in metabolic diseases.
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Role of macrophage tissue infiltration in metabolic diseases.

机译：巨噬细胞组织浸润在代谢疾病中的作用。

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PURPOSE OF REVIEW: White adipose tissue is necessary for optimal energy homeostasis and the excessive development of fat mass is clearly associated with the metabolic syndrome. The fact that adipocytes secrete a number of specific factors or 'adipokines' has forced a reassessment of the involvement of adipose tissue in a wide range of physiological and pathophysiological processes. Obesity has recently been described as a 'low-grade' inflammatory condition, a state proposed to represent a common determinator in the genesis of obesity-associated pathologies, i.e. diabetes and atherosclerosis. RECENT FINDINGS: Recent reports of an increase in the number of macrophages that infiltrate the fat mass in obese individuals led to the suggestion that adipose tissue itself is a source and site of inflammation. SUMMARY: This review summarizes recent data on the characterization of the macrophage population in fat tissue. Their origin, fate and activation will be considered. The potential involvement of adipose tissue macrophages in the development of insulin resistance and vascular pathologies, as well as in the control of adipose tissue growth and metabolism, will be examined.
机译：审查的目的：白色脂肪组织对于最佳的能量稳态是必要的，并且脂肪过多的发展显然与代谢综合征有关。脂肪细胞分泌许多特定因子或“脂肪因子”这一事实迫使人们重新评估了脂肪组织在广泛的生理和病理生理过程中的参与程度。肥胖最近被描述为“低度”炎性疾病，该状态被提议代表肥胖相关疾病（即糖尿病和动脉粥样硬化）的起源中的共同决定因素。最近的发现：最近有报道称，肥胖个体中巨噬细胞浸润脂肪的数量增加，这提示脂肪组织本身是炎症的来源和部位。摘要：这篇综述总结了脂肪组织中巨噬细胞种群特征的最新数据。将考虑它们的起源，命运和激活。将检查脂肪组织巨噬细胞在胰岛素抵抗和血管病变的发展中以及在控制脂肪组织生长和代谢中的潜在作用。

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