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首页> 外文期刊>Current opinion in clinical nutrition and metabolic care >N-3 fatty acids and pregnancy outcomes.
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N-3 fatty acids and pregnancy outcomes.

机译：N-3脂肪酸与妊娠结局。

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PURPOSE OF REVIEW: To discuss new data from the literature on the relationship between the supply of n-3 polyunsaturated fatty acids during pregnancy and pregnancy outcomes, evaluated as the fatty acid composition of blood and breast milk, fetal and infantile development and maternal health. RECENT FINDINGS: Supplementation of alpha-linolenic acid in high doses or docosahexaenoic acid in low doses did not result in a significant enhancement of the blood docosahexaenoic acid status of the offspring. In contrast, supplementation of docosahexaenoic acid in relatively high doses led to significant increases in infantile docosahexaenoic acid values and to a significant enhancement of breast milk docosahexaenoic acid content. Electroretinogram data obtained during the first week of life and pattern-reversal visual evoked potentials investigated at 50 and 66 weeks postconception were significantly associated with the docosahexaenoic acid status of the infant at birth. Children whose mothers received docosahexaenoic acid supplementation during pregnancy and lactation scored better in mental processing tests carried out at 4 years than children whose mothers received placebo. SUMMARY: Beneficial health outcomes are more likely to result from supplementation with docosahexaenoic acid itself, rather than its precursor alpha-linolenic acid. Trials have shown that a higher maternal docosahexaenoic acid intake during pregnancy may be favourable for the visual and cognitive development of the offspring. The significant positive association between maternal docosahexaenoic acid intake during pregnancy and the children's mental processing scores at 4 years suggest that optimization of the docosahexaenoic acid status of expectant women may offer long-term developmental benefits to their children.
机译：审查目的：讨论文献中有关妊娠期间n-3多不饱和脂肪酸的供应与妊娠结局之间关系的新数据，该关系被评估为血液和母乳的脂肪酸组成，胎儿和婴儿发育以及孕产妇健康。最新发现：高剂量补充α-亚麻酸或低剂量补充二十二碳六烯酸并不能显着提高后代血液二十二碳六烯酸的状况。相反，以相对较高的剂量补充二十二碳六烯酸导致婴儿中二十二碳六烯酸的值显着增加，并且导致母乳中二十二碳六烯酸的含量显着增加。在生命的第一周获得的视网膜电图数据以及在受孕后50和66周进行的模式反转视觉诱发电位研究与婴儿出生时的二十二碳六烯酸状态显着相关。母亲在怀孕和哺乳期补充二十二碳六烯酸的孩子在4岁时进行的智力加工测试中得分比母亲接受安慰剂的孩子更好。摘要：有益健康的结果更有可能来自补充二十二碳六烯酸本身而不是其前体α-亚麻酸。试验表明，怀孕期间孕妇增加二十二碳六烯酸的摄入可能对后代的视觉和认知发育有利。孕妇怀孕期间二十二碳六烯酸的摄入量与4岁儿童的心理加工成绩之间存在显着的正相关关系，这表明优化孕妇的二十二碳六烯酸的状况可能为其子女带来长期的发展益处。

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