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首页> 外文期刊>Current opinion in clinical nutrition and metabolic care >Measurement of gastric emptying by octanoate metabolism.
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Measurement of gastric emptying by octanoate metabolism.

机译：通过辛酸代谢测量胃排空。

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摘要

PURPOSE OF REVIEW: Since its introduction just over 10 years ago, there have been a number of studies that have used the octanoate breath test to assess gastric emptying. Although use of the method is on the increase (the number of gastric emptying studies published on PubMed using the octanoate breath test has doubled between the periods 1997-2000 and 2001-2004 compared with a drop of approximately 20% in the use of scintigraphy over the same periods), the methodology has not achieved universal acceptance, primarily because it can provide results comparable to established techniques only indirectly. RECENT FINDINGS: Recent methods for overcoming this difficulty are reviewed, including modified methods for breath test interpretation and the application of the related saliva test. The latter promises to be useful as a non-invasive proxy for established techniques, such as scintigraphy, for further validation of the breath test. Recent applications of octanoate-based methods are briefly considered. SUMMARY: A novel approach detailed in this review for breath test interpretation, where the bicarbonate pool is modelled as a single compartment, could prove useful for obtaining breath test gastric emptying parameters that are directly comparable with those obtained from the gold standard, gamma scintigraphy. In combination with the saliva test, this could add credence to use of the octanoate breath test as a clinically accepted diagnostic tool, in addition to its potential in research.
机译：审查目的：自从10年前推出以来，已有许多研究使用辛酸呼气试验评估胃排空情况。尽管该方法的使用正在增加（1997年至2000年至2001年至2004年期间，使用辛酸呼气试验在PubMed上发表的胃排空研究的数量增加了一倍，相比之下，闪烁显像术的使用量下降了约20％）。同一时期），该方法尚未获得普遍接受，主要是因为它只能间接地提供可与现有技术相比的结果。最近的发现：综述了克服这一困难的最新方法，包括呼气试验解释的改进方法和相关唾液试验的应用。后者有望作为已确立的技术（如闪烁显像）的非侵入性代理，用于进一步验证呼气测验。简要考虑了基于辛酸酯的方法的最新应用。摘要：本综述中详细介绍的一种用于呼气试验解释的新颖方法（其中碳酸氢盐池被建模为单个隔室）可以证明对获得呼气试验的胃排空参数非常有用，该参数可以直接与从金标准伽玛闪烁显像法获得的参数相比较。与唾液测试相结合，这不仅可以提高辛酸呼吸测试作为临床公认的诊断工具的可信度，还可以增加其可信度。

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