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首页> 外文期刊>Current opinion in clinical nutrition and metabolic care >Regulation of skeletal muscle protein metabolism in catabolic states.
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Regulation of skeletal muscle protein metabolism in catabolic states.

机译：分解代谢状态下骨骼肌蛋白质代谢的调节。

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PURPOSE OF REVIEW: This review highlights recent publications dealing with the nature of the in-vivo response of skeletal muscle to critical illness and approaches to attenuating this response. Studies focused on molecular mechanisms of muscle catabolism are not reviewed. RECENT FINDINGS: The general areas covered are the metabolic response to stress, particularly regarding the relationship between muscle protein breakdown, amino acid availability, and muscle protein synthesis. The impact of the profile of amino acids in the context of protein/amino acid intake is also discussed. Advances in our understanding of the hormonal response are considered, and use of insulin therapy to slow muscle catabolism is discussed. SUMMARY: Muscle catabolism is a fundamental response to severe stress, and the resulting amino acid efflux from muscle provides important precursors for protein synthesis in other parts of the body. The nature of this response (i.e. transport kinetics favoring efflux of amino acids from muscle) makes amelioration of the catabolic response of muscle with nutrition alone very difficult. Many approaches have been used to reverse catabolism, mostly involving various anabolic hormones. Recent studies using insulin therapy are particularly intriguing because of the low cost and powerful anabolic stimulus of insulin.
机译：审查的目的：这篇综述重点介绍了有关骨骼肌对重症的体内反应的性质以及减轻这种反应的方法的最新出版物。关于肌肉分解代谢的分子机制的研究尚未审查。最近发现：涉及的一般领域是对压力的代谢反应，特别是关于肌肉蛋白质分解，氨基酸可利用性和肌肉蛋白质合成之间的关系。还讨论了氨基酸分布在蛋白质/氨基酸摄入情况下的影响。考虑到我们对荷尔蒙反应的理解方面的进展，并讨论了使用胰岛素疗法减缓肌肉分解代谢的方法。简介：肌肉分解代谢是对严重压力的基本反应，肌肉产生的氨基酸外排为人体其他部位的蛋白质合成提供了重要的前体。这种反应的性质（即有利于氨基酸从肌肉中流出的运输动力学）使得仅靠营养来改善肌肉的分解代谢反应非常困难。已经使用了许多方法来逆转分解代谢，主要涉及各种合成代谢激素。由于胰岛素的低成本和强大的合成代谢刺激，最近使用胰岛素疗法的研究特别引人入胜。

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