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Combined oral contraceptives and cervical cancer.

机译:联合口服避孕药和宫颈癌。

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摘要

PURPOSE OF REVIEW: The issue of whether there might be an increased risk of cervical cancer associated with the use of oral contraceptives has been debated for decades. Early studies found a modest association with long-term use. A literature review was performed over the past 3 years, to establish whether there is any new evidence linking cervical cancer with the use of oral contraceptives. RECENT FINDINGS: A new analysis from eight studies conducted by the International Agency for Research on Cancer and a systematic review of cervical cancer and the use of hormonal contraceptives are two recent major epidemiological links strongly suggesting the increased risk of cervical cancer (up to twofold), but only for women who were both long-term users (5 years or more) and who had persistent human papilloma virus infections of the cervix. SUMMARY: These findings seem biologically plausible, but weighing the various risks and benefits, the World Health Organization does not recommend any change in oral contraceptive use or practice.
机译:审查目的:数十年来,关于使用口服避孕药可能增加宫颈癌风险的问题一直存在争议。早期研究发现长期使用有一定的关联性。在过去三年中进行了文献综述,以确定是否有任何新证据将宫颈癌与口服避孕药联系起来。最近的发现:国际癌症研究机构进行的八项研究的最新分析以及对宫颈癌的系统评价以及激素避孕药的使用是最近两个主要的流行病学联系,强烈表明宫颈癌的风险增加(高达两倍) ,但仅适用于既长期使用(5年以上)又持续感染人宫颈乳头瘤病毒的女性。摘要:这些发现在生物学上似乎是合理的,但是权衡了各种风险和益处,世界卫生组织不建议对口服避孕药的使用或做法进行任何更改。

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