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首页> 外文期刊>Current opinion in obstetrics & gynecology >Hypertensive disorders of pregnancy: the United States perspective.
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Hypertensive disorders of pregnancy: the United States perspective.

机译：妊娠高血压疾病：美国的观点。

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Preeclampsia is a syndrome that is characterized by heterogeneous clinical and laboratory findings. The clinical findings of preeclampsia can manifest as either a maternal syndrome (hypertension, proteinuria, or various symptoms), or a fetal syndrome (growth restriction), or both . Despite extensive research in the pathogenesis of preeclampsia, its cause remains unknown. During the past decade, numerous pathophysiologic abnormalities have been suggested to explain the mechanisms leading to the development of preeclampsia. Some of these mechanisms have included impaired trophoblast differentiation and invasion, placental and endothelial dysfunction, immune maladaptation to paternal antigens, and exaggerated systemic inflammatory response. Preeclampsia is a heterogeneous disorder, however, for which the mechanisms can differ in women with various risk factors (healthy nulliparous women with normal body mass index versus those with preexisting microvascular disease, renal disease, or thrombophilias). In addition, the diagnostic criteria for preeclampsia and its subtypes (mild, severe, superimposed) have not been consistent among the published studies. As a result, research in this area has not resulted in significant improvement in methods of prediction, markers for confirming the diagnosis in various subtypes, prevention, or management of this disorder.The aim of this current review is to give an update on recently published reports on this subject, with emphasis on publications during the past 2 years, particularly the United States view of these publications.
机译：子痫前期是一种以临床和实验室发现不同为特征的综合征。先兆子痫的临床表现可以表现为母体综合征（高血压，蛋白尿或各种症状）或胎儿综合征（生长受限），或两者兼而有之。尽管在先兆子痫的发病机理上进行了广泛的研究，但其原因仍然未知。在过去的十年中，已经提出了许多病理生理异常来解释导致先兆子痫发展的机制。这些机制中的一些机制包括滋养层细胞的分化和侵袭受损，胎盘和内皮功能障碍，对父体抗原的免疫适应不良以及过度的全身炎症反应。先兆子痫是一种异质性疾病，但是，其机制可能在具有各种危险因素的妇女中有所不同（体重指数正常的健康未产妇与先前患有微血管疾病，肾病或血栓形成症的妇女）。此外，先兆子痫及其亚型（轻度，重度，叠加）的诊断标准在已发表的研究中并不一致。结果，该领域的研究并未在预测方法，用于确认该亚型的各种亚型中的诊断的标记物，预防或控制该疾病方面取得显着改善。本综述的目的是对最近发表的文献进行更新。关于这一主题的报告，重点是过去两年中的出版物，特别是美国对这些出版物的看法。

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