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Locus Coeruleus in time with the making of memories

机译:记忆的发生与时俱进

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Over the past decades studies of the neurobiology of memory were largely restricted to consideration of cellular and molecular events taking place immediately or shortly after training, the so-called consolidation period. More recent views have recognized that the memory process includes sensory processing, orienting of attention, retrieval, encoding, and subsequent consolidation. Advances in biotechnology are providing new tools to gain insights at every level of the memory process. New data from experiments employing high definition fMRI are confirming the role of the Locus Coeruleus (LC) noradrenergic system in reorienting of attention and in cognitive flexibility. Electrophysiological studies show new task-related activation of these neurons and learning-related off line activation and suggest a temporal relationship between LC spiking and cortical oscillations in the theta and gamma frequencies.
机译:在过去的几十年中,记忆神经生物学的研究主要局限于考虑在训练后立即或不久即所谓的巩固期发生的细胞和分子事件。最近的观点已经认识到,存储过程包括感觉处理,注意力定向,检索,编码和随后的合并。生物技术的进步正在提供新的工具,以获取有关存储过程各个层面的见解。来自采用高清晰度功能磁共振成像的实验的新数据证实了蓝斑脑(RC)去甲肾上腺素能系统在重新定向注意力和认知灵活性中的作用。电生理学研究显示这些神经元的新任务相关激活和与学习相关的离线激活,并提示LC峰值与theta和gamma频率之间的皮质振荡之间存在时间关系。

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