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首页> 外文期刊>Asian Journal of Chemistry: An International Quarterly Research Journal of Chemistry >Analytical Methods for Ionic Profile of Dialysate Iron Therapy Drug Ferric Pyrophosphate Citrate By Ion Chromatography using Suppressed and Non-Suppressed Conductivity Detection
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Analytical Methods for Ionic Profile of Dialysate Iron Therapy Drug Ferric Pyrophosphate Citrate By Ion Chromatography using Suppressed and Non-Suppressed Conductivity Detection

机译：使用抑制和非抑制的电导检测，通过离子色谱法进行透析液铁疗法柠檬酸铁焦磷酸酯的离子型材的分析方法

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摘要

In present study, ionic profile of pharmaceutical drug molecule ferric pyrophosphate citrate by ion exchange chromatography using conductivity detection was carried out. Ferric pyrophosphate citrate is an iron organic complex used for hemodialysis for the chronic kidney disease patients. The drug is used as iron supplementation to balance the iron loss during the dialysis for the kidney affected patients. Anions, cation and metal ion were analyzed by ion chromatographic method. Relevant anions sulphate, phosphate, citrate and pyrophosphate were analyzed by suppressed conductivity detection. Both isocratic and gradient separation methods were developed for the anions analysis. Cation sodium was analyzed by non-suppressed conductivity detection. Metal iron was determined by direct conductivity detection. All the analyses were done covering selectivity, precision, linearity and accuracy aspects of analysis. Calibration outcome of RSD 0.4 to 3.0% and correlation coefficient values greater than 0.999 were observed during the studies. Spiking studies were done to check the accuracy of the analysis and the recovery values ranging from 93 to 110% were observed. Around 90% ionic content of the drug molecule can be characterized using the developed ion chromatographic methods. These methods can be directly applied for the routine analysis of drug in the pharmaceutical industries.
机译：在目前的研究中，进行了使用电导检测通过离子交换色谱法通过离子交换色谱法进行催化剂的药物药物分子离子型材。 Ferric焦磷酸柠檬酸盐是一种用于慢性肾病患者的血液透析的铁有机复合物。该药物用作铁补充，以平衡肾脏受影响患者的透析期间的铁损。通过离子色谱法分析阴离子，阳离子和金属离子。通过抑制电导检测分析了相关的阴离子，磷酸盐，柠檬酸盐和焦磷酸盐。为阴离子分析开发了等级和梯度分离方法。通过非抑制的电导检测分析阳离子钠。通过直接电导检测确定金属铁。所有分析都完成了涵盖了分析的选择性，精度，线性度和准确性方面。在研究期间观察到校准结果为RSD 0.4至3.0％，并且在研究期间观察到大于0.999的相关系数值。进行了尖峰研究以检查分析的准确性，观察到93〜110％的回收值。可以使用发育的离子色谱法表征约90％的药物分子离子含量。这些方法可以直接申请制药行业药物的常规分析。

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