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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >LC-MS and docking profiling reveals potential difference between the pure and crude fucoidan metabolites
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LC-MS and docking profiling reveals potential difference between the pure and crude fucoidan metabolites

机译：LC-MS和对接分析揭示了纯和粗葡萄糖代谢物之间的潜在差异

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摘要

Fucoidan, a macromolecule, a type of polysaccharide and contains high percentage of fucose and sulfate ester groups and other compounds in low percentage. In the last decades, a number of interesting biological activities have been studied so fucoidan has been major focus of interest for exploring new drugs against the leading human diseases. It is known in relation to biological pathways and function that it activates the pathways which mediate apoptosis. Using LC-MS and interdisciplincary approach, we developed our goal to elucidate the potential difference between the crude and pure fucoidan and the interaction of fucoidan with potential signaling molecules STAT4 and IL12RB2. Based on our analysis, we conclude that there is major difference between crude and pure fucoidan in terms of identified metabolites and their functional relevance. It leads to the conclusion that there are 18 functions which are common between crude and pure fucoidans, 47 functions pure fucoidan specific, and 84 functions crude fucoidan specific which leads to the conclusion that even the fucoidans obtained from the same organism behave functionally completely different between the processing states (with/without processing) while docking study with STAT4 and IL12RB2 display very strong binding between fucoidan and both these signaling molecules. (C) 2019 Published by Elsevier B.V.
机译：Fucoinean，大分子，一种多糖，含有高百分比的岩藻糖和硫酸盐酯基，其它化合物低百分比。在过去的几十年中，已经研究了许多有趣的生物学活动，因此Fucoinoidan一直是探索对抗人类疾病的新药的兴趣。它是在相对于生物途径和功能已知它激活介导的细胞凋亡途径。使用LC-MS和跨学科方法，我们开发了阐明了粗糙和纯FUCOINONAN与uCOOINON与潜在信号分子Stat4和IL12RB2的潜在差异的目标。基于我们的分析，我们得出结论，在确定的代谢物和其功能相关性方面，原油和纯Fucoidan之间存在重大差异。它的结论是，有18个功能在原油和纯Fucoidens之间常见，47个功能纯Fucoidan特异性，84个功能粗糙的岩藻糖膜，其均可结束，即使从相同的生物中获得的岩环素也在功能上完全不同地不同处理状态（带/不加工），同时使用STAT4和IL12RB2对接研究，在FUCOINONON和这些信号分子之间显示非常强的结合。 （c）2019年由elestvier b.v发布。

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