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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Antihyperglycemic and antioxidant activities of a lectin from the marine red algae, Bryothamnion seaforthii, in rats with streptozotocin-induced diabetes
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Antihyperglycemic and antioxidant activities of a lectin from the marine red algae, Bryothamnion seaforthii, in rats with streptozotocin-induced diabetes

机译：来自海洋红藻，Bryothamnion Seaforthii的凝集素的抗血糖和抗氧化活性，在大鼠中患有链脲佐菌素诱导的糖尿病

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The aim of the study was to assess the antihyperglycemic, antilipidemic, and antioxidant effects of a lectin isolated from Bryothamnion seaforthii (BSL), on rats with streptozotocin (STZ)-induced diabetes. The disease model was induced by low-dose injections of STZ. Diabetic rats were treated with NaCl 150 mM, metformin, and BSL at different concentrations. Blood collection was carried out at 0, 30, 60, 90, and 120 days after hyperglycemia confirmation via the assessment of seric glucose, total cholesterol, and triglycerides, assessment of the enzymatic levels of glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD), and the determination of insulin resistance by a homeostasis model of assessment-insulin resistance (HOMA-IR) as well as a homeostasis model of assessment of beta-cells resistance (HOMA-beta). The BSL-treated animals at all three concentrations showed a significant reduction in levels of glucose, cholesterol, total cholesterol, and triglycerides. Moreover, BSL increased the enzymatic activity of GPx and SOD. Index assessments of HOMA-IR and HOMA-beta confirmed that BSL treatment significantly decreased insulin resistance and beta-cell hypersecretion, respectively. In conclusion, BSL treatment might exert hypoglycemic and hypolipidemic effects, diminish insulin resistance, and ameliorate pancreatic beta-cell function along with enzymatic activities toward oxidative stress caused by diabetes mellitus type 2 (T2DM). (C) 2020 Elsevier B.V. All rights reserved.
机译：该研究的目的是评估从Bryothamnion Seaforthii（BSL）中分离的凝集素的凝血性，抗癫痫和抗氧化效果，在用链脲佐菌素（STZ）诱导的糖尿病大鼠。通过低剂量注射STZ诱导疾病模型。用NaCl 150mM，二甲双胍和不同浓度的BSL处理糖尿病大鼠。通过评估丝血糖，总胆固醇和甘油三酯，评估谷胱甘肽过氧化物酶（GPX），过氧化氢酶（猫），过氧化氢酶（猫），过糖苷酶（GPX），过氧化氢酶（猫），和超氧化物歧化酶（SOD），以及通过评估 - 胰岛素抵抗（HOMA-IR）的稳态模型的胰岛素抵抗的测定以及β细胞抗性评估的稳态模型（HOMA-β）。所有三种浓度的BSL处理的动物显示出葡萄糖，胆固醇，总胆固醇和甘油三酯水平的显着降低。此外，BSL增加了GPX和SOD的酶活性。 HOMA-IR和HOMA-β的指标评估证实，BSL治疗分别显着降低了胰岛素抵抗和β细胞的过度折叠。总之，BSL治疗可能发挥降血糖和低血脂效应，递减胰岛素抵抗力，并且改善胰腺β细胞功能以及由糖尿病型2（T2DM）引起的氧化应激的酶活性。 （c）2020 Elsevier B.v.保留所有权利。

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