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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Mechanical and biological properties of chitin/polylactide (PLA)/hydroxyapatite (HAP) composites cast using ionic liquid solutions
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Mechanical and biological properties of chitin/polylactide (PLA)/hydroxyapatite (HAP) composites cast using ionic liquid solutions

机译：用离子液体溶液施放几丁质/聚物（PLA）/羟基磷灰石（HAP）复合材料的机械和生物学性质

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This research investigates the potential development of lobster shell waste-derived chitin reinforced with poly (lactic acid) (PLA) and nano-hydroxyapatite (nHAP) into new materials with potentially superior mechanical and thermal properties for biomedical applications. The ionic liquid 1-ethyl-3-methylimidazolium acetate ([C2mim][OAc]) was used as a solvent to prepare chitin/PLA/nHAP composites. The effect of variation of the polymer concentrations on the conduct of the resulting composite was explored. The detailed physico-mechanical, thermal and surface morphology properties were evaluated with different thermal and optical characterization techniques. When the concentration of PLA in the composite was increased from 20 to 80 wt%, the tensile strength improved by similar to 77% while the elongation at break and the toughness of the material decreased significantly. The addition of hydroxyapatite was observed to improve strength of the composites up to 140% with an increase in elongation at break up to 465%. Cell growth study show that the composite materials support the growth and proliferation of Ocy 454 osteocyte cells. The materials were shown to have no effect on osteocyte gene expression, as well as minimal cytotoxicity and biodegradability. These results reveal that the biocomposites would be suitable candidates for use in bone regeneration that are not exposed to excessive forces. (C) 2019 Elsevier B.V. All rights reserved.
机译：本研究研究了用聚（乳酸）（PLA）和纳米 - 羟基磷灰石（NHAP）加强的龙虾壳废废衍生的甲壳素的潜在发展，并将含有潜在优越的生物医学应用的机械和热性能的新材料。离子液体1-乙基-3-甲基咪唑鎓乙酸盐（[C2mim] [OAC]）用作制备丁蛋白/ PLA / NHAP复合材料的溶剂。探讨了聚合物浓度对所得复合材料进行的变化的影响。用不同的热和光学表征技术评估详细的物理机械，热和表面形态特性。当复合材料中PLA的浓度从20％增加到20％至80wt％时，拉伸强度提高到77％，而断裂处的伸长率和材料的韧性显着降低。观察到加入羟基磷灰石，以提高复合材料的强度，高达140％，随着断裂的伸长率增加至465％。细胞生长研究表明，复合材料支持OCY 454骨细胞细胞的生长和增殖。显示材料对骨细胞基因表达没有影响，以及最小的细胞毒性和生物降解性。这些结果表明，生物复合材料是合适的候选者，用于骨再生的不暴露于过度力。 （c）2019 Elsevier B.v.保留所有权利。

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