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Alternative methodology for chitin/hydroxyapatite composites using ionic liquids and supercritical fluid technology

机译:使用离子液体和超临界流体技术的几丁质/羟基磷灰石复合材料的替代方法

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摘要

An alternative, green method was used to develop chitin-based biocomposite (ChHA) materials by an integrated strategy using ionic liquids, supercritical fluid drying, and salt leaching. ChHA matrices were produced by dissolving chitin in 1-butyl-methylimidazolium acetate along with salt and/or hydroxyapatite particles and then subsequent drying. The ChHA composite formed had a heterogeneous porous microstructure with 65%–85% porosity and pore sizes in the range of 100–300 µm. The hydroxyapatite was found to be well distributed within the composite structures and had a positive effect in the viability and proliferation of osteoblast-like cells, in vitro. Our findings indicate that these ChHA matrices have potential applications in bone tissue engineering.
机译:通过使用离子液体,超临界流体干燥和盐浸的综合策略,另一种绿色方法被用于开发基于甲壳质的生物复合材料(ChHA)。通过将几丁质与盐和/或羟基磷灰石颗粒一起溶解在乙酸1-丁基-甲基咪唑鎓盐中,然后干燥,从而制得ChHA基质。形成的ChHA复合材料具有非均质的多孔微观结构,其孔隙率在65%至85%之间,孔径范围在100至300 µm之间。发现羟基磷灰石在复合结构内分布良好,并且在体外对成骨细胞样细胞的活力和增殖具有积极作用。我们的发现表明,这些ChHA基质在骨组织工程中具有潜在的应用。

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