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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Mucoadhesive improvement of alginate microspheres as potential gastroretentive delivery carrier by blending with Bletilla striata polysaccharide
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Mucoadhesive improvement of alginate microspheres as potential gastroretentive delivery carrier by blending with Bletilla striata polysaccharide

机译：用Bletilla Striata多糖混合通过混合藻酸盐微球的改善藻酸盐微球

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摘要

As polysaccharide from Bletilla striata (BSP) was anticipated with mucoadhesive improvement in sodium alginate (SA) rnicrospheres, BSP was mixed with SA to construct a composite microsphere to retain in the gastrointestinal tract for a long time. The morphological properties, particle size and thermodynamic properties of the microspheres in combination with comprehensive evaluations in the swelling properties, mutin adsorption, ex vivo and in vivo gastric retention were determined to characterize the mucoadhesion of SA-BSP blend microspheres. Results showed that the prepared microspheres were discrete and spherical. The addition of BSP increased flexibility and reduced rigidity of SA microsphere. Furthermore, the swelling property, mucin adsorption ability and the retention rate on the gastric mucosa of SA matrix were increased after blending with BSP. Mucoadhesion tests showed the SA-BSP microspheres stayed much longer in rats' stomach than the SA microsphere did. Above all, the SA-BSP microspheres with the enhanced mucoadhesion suggested being a potential drug carrier in developing the gastroretentive drug delivery system. (C) 2019 Elsevier B.V. All rights reserved.
机译：随着来自Bletilla Striata（BSP）的多糖预期，用藻酸钠（SA）Rnicropheres含有粘膜粘附性，BSP与SA混合以构建复合微球，长时间保持胃肠道。确定微球的形态学性质，粒度和热力学性质与肿胀性质，蛋白质吸附，离体和体内胃保留的综合评价组合，表征了SA-BSP混合物微球的粘膜。结果表明，制备的微球是离散和球形的。添加BSP的灵活性和SA微球的刚性降低。此外，与BSP混合后，溶胀性质，粘膜吸附能力和SA基质的胃粘膜上的保留率增加。粘膜粘附试验显示SA-BSP微球比SA微球在大鼠胃中保持得多。最重要的是，具有增强的粘膜的SA-BSP微球，表明在开发胃暴觉药物递送系统时是一种潜在的药物载体。 （c）2019 Elsevier B.v.保留所有权利。

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