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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Okra polysaccharides/gelatin complex coacervate as pH-responsive and intestine-targeting delivery protects isoquercitin bioactivity
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Okra polysaccharides/gelatin complex coacervate as pH-responsive and intestine-targeting delivery protects isoquercitin bioactivity

机译：秋葵多糖/明胶复合物作为pH-响应和肠靶向递送保护异喹啉生物活性

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摘要

Okra polysaccharides (OPs) belong to RG I pectin branched with neutral saccharide side chains, which possesses distinctive structure and physicochemical properties from the commonly used HG pectin. Until now, the application of RG I pectin as wall material of microcapsule remains unclear. Here, we obtained OPs/gelatin complex coacervate at the maximum yield of 86.8% (pH 3.5, gelatin/OPs ratio 9:1 and 2% (w/v) total polymer concentration) by response surface methodology. Isoquercitin (IQ)-loaded OPs/gelatin complex coacervate (OGIQ) showed porous spongy-like surface structure with average particle size, encapsulation efficiency and surface porosity at 334 nm, 81.6% and 31.9%, respectively. OGIQ was found to be pH-responsive and intestine-targeting. The IQ release rate of OGIQ was assayed to be 89.4% in intestine fluid and below 2% in acidic and simulated gastric digestion, respectively. Accordingly, embedding in OGIQ protected IQ in digestion and improved its postdigestive alpha-glucosidase inhibitory rate by 88.7%. The differential scanning calorimetry curves showed that OGIQ effectively prevented IQ from thermal decomposition. The XRD, FT-IR and CD spectra indicated that IQ was embedded in OGIQ in amorphous state by hydrogen bonds and electrostatic interaction. Compared with HG, the neutral saccharide side chains of OPs could induce different secondary conformation change of gelatin during complex coacervation. (C) 2020 Elsevier B.V. All rights reserved.
机译：秋葵多糖（OPS）属于含有中性糖侧链的Rg I果胶，其具有来自常用的Hg果白的独特结构和物理化学性质。到目前为止，RG I果胶作为微胶囊壁材料的应用仍不清楚。这里，通过响应表面方法，我们以86.8％（pH3.5，小醇/ OPS比例9：1和2％（w / v）总分比浓度）的最大收率获得Ops / gelatin复合物。异喹啉（IQ） - 加载的OPS /明胶复合凝集（OGIQ）显示多孔海绵状表面结构，分别为334nm，81.6％和31.9％的平均粒度，包封效率和表面孔隙率。发现ogiq被发现是pH-响应和肠靶向。 OGIQ的IQ释放率分别在肠液中测定为89.4％，分别低于酸性和模拟胃消化的2％。因此，在消化中嵌入OGIQ保护的IQ，并改善其后消化性α-葡糖苷酶抑制率88.7％。差分扫描量热法曲线显示OGIQ有效地防止了IQ热分解。 XRD，FT-IR和CD光谱表明IQ通过氢键和静电相互作用在非晶态中嵌入OGIQ中。与汞相比，OPS的中性糖侧链可在复合凝聚期间诱导明胶的不同二次构象变化。 （c）2020 Elsevier B.v.保留所有权利。

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