Structural features of HtpG(Mtb) and HtpG-ESAT6(Mtb) vaccine antigens against tuberculosis: Molecular determinants of antigenic synergy and cytotoxicity modulation

Moreira Miguel; Ruggiero Alessia; Esposito Luciana; Choi Han-Gyu; Kim Hwa-Jung; Berisio Rita

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Structural features of HtpG(Mtb) and HtpG-ESAT6(Mtb) vaccine antigens against tuberculosis: Molecular determinants of antigenic synergy and cytotoxicity modulation

机译：HTPG（MTB）和HTPG-ESAT6（MTB）疫苗抗原对结核病的结构特征：抗原协同作用和细胞毒性调节的分子决定因素

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Vaccine development against tuberculosis is an urgent need as the only available vaccine, M. bovis Bacillus Calmette Guerin (BCG), is unable to provide significant protection in adults. Among newly identified antigens, Rv2299c is an excellent candidate for the rational design of an effective multi-antigenic TB vaccine. Also, when fused to the T cell antigen ESAT6, it becomes highly effective in boosting BCG immunization and it adopts low cytotoxicity compared to ESAT6.

机译：对肺结核的疫苗开发是一种迫切需要作为唯一可用的疫苗，M.Bovis Bacillus Calmette Guerin（BCG），无法在成年人中提供显着的保护。在新鉴定的抗原中，RV2299C是有效多抗原TB疫苗的理性设计的优异候选者。此外，当与T细胞抗原ESAT6融合时，它在增强BCG免疫方面变得非常有效，并且与ESAT6相比，它采用低细胞毒性。

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来源
《International Journal of Biological Macromolecules: Structure, Function and Interactions》 |2020年第1期|共13页
作者
Moreira Miguel; Ruggiero Alessia; Esposito Luciana; Choi Han-Gyu; Kim Hwa-Jung; Berisio Rita;
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作者单位

CNR Ist Biostrutture &

Bioimmagini Via Mezzocannone 16 I-80134 Naples Italy;

CNR Ist Biostrutture &

Bioimmagini Via Mezzocannone 16 I-80134 Naples Italy;

CNR Ist Biostrutture &

Bioimmagini Via Mezzocannone 16 I-80134 Naples Italy;

Chungnam Natl Univ Coll Med Dept Microbiol &

Med Sci Daejeon South Korea;

Chungnam Natl Univ Coll Med Dept Microbiol &

Med Sci Daejeon South Korea;

CNR Ist Biostrutture &

Bioimmagini Via Mezzocannone 16 I-80134 Naples Italy;

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正文语种 eng
中图分类生物大分子的结构和功能;
关键词
Protein structure; Vaccine; Chaperone; Tuberculosis; Conformation; Ligand binding;

机译：蛋白质结构;疫苗;伴侣;结核;构象;配体结合;

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1. Structural features of HtpG(Mtb) and HtpG-ESAT6(Mtb) vaccine antigens against tuberculosis: Molecular determinants of antigenic synergy and cytotoxicity modulation [J] . Moreira Miguel, Ruggiero Alessia, Esposito Luciana, International Journal of Biological Macromolecules: Structure, Function and Interactions . 2020,第1期

机译：HTPG（MTB）和HTPG-ESAT6（MTB）疫苗抗原对结核病的结构特征：抗原协同作用和细胞毒性调节的分子决定因素
2. Differences in IgG responses against infection phase related Mycobacterium tuberculosis (Mtb) specific antigens in individuals exposed or not to Mtb correlate with control of TB infection and progression [J] . Coppola Mariateresa, Arroyo Leonar, van Meijgaarden Krista E., Tuberculosis . 2017,第期

机译：暴露或不与MTB暴露或不与Tb感染和进展相关的个体中的IgG响应对感染阶段相关分枝杆菌（MTB）特异性抗原的差异
3. The effect of HIV coinfection, HAART and TB treatment on cytokine/chemokine responses to Mycobacterium tuberculosis (Mtb) antigens in active TB patients and latently Mtb infected individuals [J] . Kassa Desta, de Jager Wilco, Gebremichael Gebremedhin, Tuberculosis . 2016,第1期

机译：HIV合并感染，HAART和TB治疗对活动性TB患者和潜在Mtb感染个体对结核分枝杆菌（Mtb）抗原的细胞因子/趋化因子反应的影响
4. Novel Bacterial Delivery System with Attenuated Salmonella typhimurium Carrying Plasmid Encoding Mtb Antigen 85A for Mucosal Immunization Establishment of Proof of Principle in TB Mouse Model [C] . SHREEMANTA K. PARIDA, KRIS HUYGEN, BERNHARD RYFFEL, International Conference on Natural Products and Molecular Medicine . 2005

机译：新型细菌输送系统，具有减毒沙门氏菌培养质粒编码MTB抗原85A，用于粘膜免疫，在TB小鼠模型中的原理证明
5. The influence of Rel(Mtb) on the expression of immunoregulatory antigens in Mycobacterium tuberculosis. [D] . Lau-Bonilla, Dalia. 2008

机译：Rel（Mtb）对结核分枝杆菌免疫调节抗原表达的影响。
6. Sequence conservation analysis and in silico human leukocyte antigen-peptide binding predictions for the Mtb72F and M72 tuberculosis candidate vaccine antigens [O] . Marie-Cécile Mortier, Erik Jongert, Pascal Mettens, 2015

机译：Mtb72F和M72结核候选疫苗抗原的序列保守性分析和计算机人白细胞抗原肽结合预测
7. Sequence conservation analysis and in silico human leukocyte antigen-peptide binding predictions for the Mtb72F and M72 tuberculosis candidate vaccine antigens [O] . Marie-Cécile Mortier, Erik Jongert, Pascal Mettens, 2015

机译：Mtb72F和M72结核候选疫苗抗原的序列保守性分析和计算机人类白细胞抗原-肽结合预测
8. Comparative Structural Analysis of HLA-A2 Antigens Distinguishable by Cytotoxic T Lymphocytes. Variants M7 and DR1 [R] . Krangel, M. S., Taketani, S., Biddison, W. E., 1982

机译：细胞毒性T淋巴细胞可区分的HLa-a2抗原的比较结构分析。变种m7和DR1

Structural features of HtpG(Mtb) and HtpG-ESAT6(Mtb) vaccine antigens against tuberculosis: Molecular determinants of antigenic synergy and cytotoxicity modulation

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