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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Sericin/RBA embedded gellan gum based smart nanosystem for pH responsive drug delivery
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Sericin/RBA embedded gellan gum based smart nanosystem for pH responsive drug delivery

机译：硅粉/ RBA嵌入式Gellan Gulan Gul型智能纳米系统，用于pH响应药物递送

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摘要

Polysaccharides protein complex offers a green alternative to synthetic polymers in the drug delivery system. Sericin (SC), a natural protein, in combination with rice bran albumin (RBA) and gellan gum (GG) forms a green based protein polysaccharide complex. The sericin functionalized gellan gum-rice bran (SC-GG-RBA) nano composites were characterized by different characterization techniques. It shows their prominent ability in balancing the biocompatibility, stability, biodegradability, and functionality of nanocarriers. The nanocomposites exhibited spherical shape with core protein-polysaccharide structures, and the average size was about 218 nm. High amount of Doxorubicin (DOX) was encapsulated into SC-GG-RBA nanocomposites in order to investigate the effective drug release in acidic tumor environment. DOX of 84% was released in vitro condition after 120 h in pH 4.0. DOX loaded green nanocomposites shows IC50 5 mu g/mL which was very low compared to free DOX of 9 mu/mL after treatment with MCF-7 cells. Only 42% of cells were survived after treatment with green nano composites. This was due to the effective uptake of nanomaterial by cancer cells and direct release of DOX in cytoplasmic region. Such high performance green nanocomposites have great potential in expanding the utilization of biomaterial from natural resources and development of sensible application in biomedical field. (C) 2018 Elsevier B.V. All rights reserved.
机译：多糖蛋白质复合物在药物递送系统中提供了一种绿色替代合成聚合物。与米糠白蛋白（RBA）和Gellan Gul（GG）组合的胺蛋白（SC），一种天然蛋白质形成绿基蛋白质多糖复合物。通过不同的表征技术表征了胺官能化的Gellan Gul米麸麸（SC-GG-RBA）纳米复合材料。它显示了平衡纳米载体的生物相容性，稳定性，生物降解性和功能性的突出能力。纳米复合材料表现出具有核心蛋白 - 多糖结构的球形形状，平均尺寸为约218nm。将大量的多柔比星（DOX）包封在SC-GG-RBA纳米复合材料中，以研究酸性肿瘤环境中的有效药物释放。在pH 4.0中120小时后，DOX为84％的体外释放。 Dox负载的绿色纳米复合材料显示IC505μg/ ml，与MCF-7细胞处理后的9μ/ mL的游离DOx相比非常低。用绿色纳米复合材料处理后，只能存活42％的细胞。这是由于癌细胞纳米材料的有效吸收，并在细胞质区域中的DOX直接释放。这种高性能的绿色纳米复合材料在扩大自然资源利用和生物医学领域中的明智应用的发展中具有巨大潜力。 （c）2018年elestvier b.v.保留所有权利。

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