Lack of Association between Genetic Polymorphism of Circadian Genes (PER2, PER3, CLOCK and OX2R) with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population (Circadian Genes, Late-Onset Depression and Alzheimer's Disease)

Pereira Patricia Araujo; Alvim-Soares Antonio; Camargos Bicalho Maria Aparecida; de Moraes Edgar Nunes; Malloy-Diniz Leandro; de Paula Jonas Jardim; Romano-Silva Marco Aurelio; Miranda Debora Marques

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Lack of Association between Genetic Polymorphism of Circadian Genes (PER2, PER3, CLOCK and OX2R) with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population (Circadian Genes, Late-Onset Depression and Alzheimer's Disease)

机译：在巴西人群中，昼夜节律基因（PER2，PER3，CLOCK和OX2R）的遗传多态性与迟发性抑郁症和阿尔茨海默氏病之间缺乏关联（昼夜节律基因，迟发性抑郁症和阿尔茨海默氏病）

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Objectives: This study aims to evaluate the association between polymorphisms in circadian genes and Alzheimer's disease (AD) and/or late-onset depression (LOD). AD pathology leads to circadian disturbances, with clear negative influence on quality of life. In addition, there is an increasing evidence that regulators of circadian system have effects on AD and LOD pathology.

机译：目的：本研究旨在评估昼夜节律基因多态性与阿尔茨海默氏病（AD）和/或迟发性抑郁症（LOD）之间的关联。 AD病理会导致昼夜节律紊乱，对生活质量产生明显的负面影响。另外，越来越多的证据表明，昼夜节律系统的调节剂对AD和LOD病理有影响。

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来源
《Current Alzheimer research》 |2016年第12期|共10页
作者
Pereira Patricia Araujo; Alvim-Soares Antonio; Camargos Bicalho Maria Aparecida; de Moraes Edgar Nunes; Malloy-Diniz Leandro; de Paula Jonas Jardim; Romano-Silva Marco Aurelio; Miranda Debora Marques;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Alzheimer's disease (AD); CLOCK; gene; Late-onset depression (LOD); Orexin receptor 2 (OX2R); period homolog (PER); Single-nucleotide polymorphism (SNP);

机译：阿尔茨海默氏病（AD）;时钟;基因;迟发性抑郁症（LOD）;Orexin受体2（OX2R）;周期同源物（PER）;单核苷酸多态性（SNP）;

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1. Lack of Association between Genetic Polymorphism of Circadian Genes (PER2, PER3, CLOCK and OX2R) with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population (Circadian Genes, Late-Onset Depression and Alzheimer's Disease) [J] . Pereira Patricia Araujo, Alvim-Soares Antonio, Camargos Bicalho Maria Aparecida, Current Alzheimer research . 2016,第12期

机译：在巴西人群中，昼夜节律基因（PER2，PER3，CLOCK和OX2R）的遗传多态性与迟发性抑郁症和阿尔茨海默氏病之间缺乏关联（昼夜节律基因，迟发性抑郁症和阿尔茨海默氏病）
2. Ubc9 gene polymorphisms and late-onset Alzheimer's disease in the Korean population: a genetic association study. [J] . Ahn K, Song JH, Kim DK Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2009,第3期

机译：Ubc9基因多态性与朝鲜族人群晚发性阿尔茨海默氏病：一项遗传关联研究。
3. Lack of Genetic Association Between TREM2 and Late-Onset Alzheimer's Disease in a Japanese Population [J] . Miyashita Akinori, Wen Yanan, Kitamura Nobutaka, Journal of Alzheimer's disease: JAD . 2014,第4期

机译：在日本人群中，TREM2与晚期阿尔茨海默氏病之间缺乏遗传关联
4. Association of PS1 Gene Polymorphisms with Alzheimer's Disease in Chinese Population: A Meta-Analysis of Case-Control Studies [C] . Yaodong Zhang, Yong Xu, Hongwei Nei Information technology and agricultural engineering . 2011

机译：PS1基因多态性与中国人群阿尔茨海默氏病的关联：病例对照研究的荟萃分析
5. Investigation of genetic susceptibility to late-onset Alzheimer disease through genomic convergence. [D] . Liang, Xueying. 2007

机译：通过基因组收敛研究迟发性阿尔茨海默病的遗传易感性。
6. Association between Mitofusin 2 Gene Polymorphisms and Late-Onset Alzheimers Disease in the Korean Population [O] . Young Jong Kim, Jin Kyung Park, Won Sub Kang, 2017

机译：丝裂菌素2基因多态性与朝鲜族人群晚发型阿尔茨海默氏病之间的关联
7. Genetic Association of a Cystatin C Gene Polymorphism With Late-Onset Alzheimer Disease [O] . Ulrich Finckh 2000

机译：晚期发病性阿尔茨海默病的胱抑素C基因多态性的遗传学缔章

Lack of Association between Genetic Polymorphism of Circadian Genes (PER2, PER3, CLOCK and OX2R) with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population (Circadian Genes, Late-Onset Depression and Alzheimer's Disease)

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