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首页> 外文期刊>Environmental Science and Pollution Research >Genetic damage in human populations at mining sites in the upper basin of the San Jorge River, Colombia
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Genetic damage in human populations at mining sites in the upper basin of the San Jorge River, Colombia

机译：在哥伦比亚圣豪尔赫河上部盆地采矿地区的人口遗传损伤

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Contamination with mining wastes affects the environmental health and public, especially the human populations that live in these environments. The aim of this study was to evaluate the genotoxicity and levels of mercury (Hg) and arsenic (As) in blood samples from human populations exposed to mining activities in the upper basin of the San Jorge River. A total of 100 individuals participated in the study, 50 as an exposed group (Bocas de Ure = 15 individuals, Mina el Alacran=19 individuals, Torno Rojo = 16 individuals) and 50 individuals participated as the control group. Hg and As contents in blood samples were analyzed with atomic absorption spectrophotometry. A comet assay in peripheral blood lymphocytes and a micronucleus (MN) cytome assay (BMCyt) in exfoliated buccal cells were used to assess the effects of exposure to heavy metals on human communities located in mining areas. Higher concentrations of Hg and As were observed in human populations located in mining areas. The comet assay and BMCyt data revealed DNA damage and cell death in human communities located in mining areas. A positive association between blood arsenic and genetic damage was found. These data confirm the public health risk of the population near mining sites. Our findings suggest that populations that live at sites close to mining activities have high contents of heavy metals and genotoxic effects, representing a risk to human health.
机译：采矿废弃物的污染影响环境健康和公众，特别是生活在这些环境中的人口。本研究的目的是评估来自人口的血液样本（AS）的汞毒性和水平来自人群，从而在圣豪尔赫河上部盆地中的采矿活动中。总共有100人参加了该研究，50个作为暴露的小组（Bocas de Ure = 15个个体，Mina El Alacran = 19个人，Torno Rojo = 16个人）和50个个人参加了对照组。用原子吸收分光光度法分析Hg并随着血液样品的含量。外周血淋巴细胞中的彗星测定和剥落的口腔细胞中的微核（Mn）细胞核测定（BMCyt）用于评估暴露于矿区人类社区对重金属的影响。高浓度的Hg，并且在矿区的人口中观察到。 Comet测定和BMCyt数据显示出在矿区的人类社区中的DNA损伤和细胞死亡。发现血液砷与遗传破坏之间的阳性关联。这些数据确认了矿业地区附近人口的公共卫生风险。我们的研究结果表明，在接近采矿活动的地点生活的人口具有高含量的重金属和基因毒性作用，代表人类健康的风险。

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