Novel hybrids from lamellarin D and combretastatin A 4 as cytotoxic agents.

Shen L; Yang X; Yang

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Novel hybrids from lamellarin D and combretastatin A 4 as cytotoxic agents.

机译：来自层层蛋白D和Combretastatin A 4的新型杂交种作为细胞毒性剂。

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A new series of hybrids of lamellarin D and combretastatin A 4, 1,2-diphenyl-5,6-dihydropyrrolo [2,1-a] isoquinolines, were designed as cytotoxic agents based on principles of combination in medicinal chemistry and taking the parent compounds' different anti-proliferative mechanisms into consideration. Twenty-two novel hybrids were synthesized through a convenient route, with a key step of core pyrrole formation and evaluated for their anti-proliferative activities in vitro against K-562, A-549, SMMC-7721, SGC-7901 and HCT-116 cancer cell lines. The results showed that some hybrids had good anti-proliferative activities in low IC50 ranges.

机译：一种新的层状杂交杂种和组合杂交剂A 4,1,2-二苯基-5,6-二氢吡咯烷[2,1-a]异喹啉，基于药用化学和服用父母的组合原则作为细胞毒性剂考虑化合物的不同防扩散机制。通过方便的途径合成了二十两种新型杂交物，具有核心吡咯的关键步骤，并在体外评价k-562，a-549，smmc-7721，sgc-7901和hct-116的抗增殖活性癌细胞系。结果表明，一些杂交种在低IC50范围内具有良好的抗增殖活动。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2010年第1期|共8页
作者
Shen L; Yang X; Yang;
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ZJU-ENS Joint Laboratory of Medicinal Chemistry College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China.;

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正文语种 eng
中图分类医药、卫生;劳动卫生;
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1. Novel hybrids from lamellarin D and combretastatin A 4 as cytotoxic agents. [J] . Shen L, Yang X, Yang European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第1期

机译：来自薄片蛋白D和康普他汀A 4的新型杂种作为细胞毒剂。
2. Novel hybrids from lamellarin D and combretastatin A 4 as cytotoxic agents. [J] . Shen L, Yang X, Yang European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第1期

机译：来自层层蛋白D和Combretastatin A 4的新型杂交种作为细胞毒性剂。
3. 4,5-Diaryl-1H-pyrrole-2-carboxylates as combretastatin A-4/lamellarin T hybrids: Synthesis and evaluation as anti-mitotic and cytotoxic agents [J] . Martin G. Banwell, Ernest Hamel, David C. R. Hockless, Bioorganic and medicinal chemistry . 2006,第13期

机译：4,5-二芳基-1H-吡咯-2-羧酸盐作为康维他汀A-4 / lamellarin T杂化物：合成和评估作为抗有丝分裂剂和细胞毒性剂
4. Cytotoxicity Evaluation of Chitosan/Apatite/Vitamin E Hybrid Films [C] . Sousam W.J.B., Almeida K.V., Cardoso M.J.B., World biomaterials congress . 2012

机译：壳聚糖/磷灰石/维生素E杂化膜的细胞毒性评价
5. Synthesis and Biological Evaluation of Novel Resveratrol and Combretastatin A4 Derivatives as Potent Anti-Cancer Agents. [D] . Madadi, Nikhil Reddy. 2014

机译：新型白藜芦醇和Combretastatin A4衍生物作为强效抗癌药的合成及生物学评价。
6. Antineoplastic Agents. 565. Synthesis of Combretastatin D-2 Phosphate and Dihydro-combretastatin D-2 [O] . George R. Pettit, Peter D. Quistorf, Jeremy A. Fry, -1

机译：抗肿瘤药。考布他汀的合成565. d-2和磷酸二氢考布他汀d-2
7. Design and synthesis of pironetin analogue/combretastatin A-4 hybrids containing a 1,2,3-triazole ring and evaluation of their cytotoxic activity [O] . Vilanova Gallén Concepción, Torijano Gutiérrez Sandra Adela, Díaz Oltra Santiago, 2015

机译：设计和合成含有1,2,3-三唑环的pironetin类似物/ combretastatin a-4杂种并评估其细胞毒活性
8. Curcumin-Combretastatin Nanocells as Breast Cancer Cytotoxic and Antiangiogenic Agent [R] . Reeves, A. E., Wickstrom, E., Vinogradov, S. V. 2008

机译：姜黄素 - Combretastatin纳米细胞作为乳腺癌细胞毒性和抗血管生成剂

Novel hybrids from lamellarin D and combretastatin A 4 as cytotoxic agents.

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